Protein Info for ABIE41_RS12365 in Bosea sp. OAE506

Annotation: monovalent cation:proton antiporter-2 (CPA2) family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 602 transmembrane" amino acids 6 to 27 (22 residues), see Phobius details amino acids 35 to 53 (19 residues), see Phobius details amino acids 59 to 78 (20 residues), see Phobius details amino acids 90 to 111 (22 residues), see Phobius details amino acids 117 to 135 (19 residues), see Phobius details amino acids 155 to 177 (23 residues), see Phobius details amino acids 183 to 205 (23 residues), see Phobius details amino acids 212 to 234 (23 residues), see Phobius details amino acids 240 to 259 (20 residues), see Phobius details amino acids 271 to 291 (21 residues), see Phobius details amino acids 297 to 319 (23 residues), see Phobius details amino acids 331 to 354 (24 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 19 to 376 (358 residues), 221.4 bits, see alignment E=1.8e-69 TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 19 to 287 (269 residues), 276.5 bits, see alignment E=1.3e-86 PF02254: TrkA_N" amino acids 405 to 517 (113 residues), 76.2 bits, see alignment E=2.7e-25

Best Hits

Swiss-Prot: 44% identical to KEFB_KLEP3: Glutathione-regulated potassium-efflux system protein KefB (kefB) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K11747, glutathione-regulated potassium-efflux system protein KefB (inferred from 64% identity to mci:Mesci_4093)

Predicted SEED Role

"putative Glutathione-regulated potassium-efflux system protein KefB" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (602 amino acids)

>ABIE41_RS12365 monovalent cation:proton antiporter-2 (CPA2) family protein (Bosea sp. OAE506)
MAAEGLTGDLIKVVSLLGAGVVAVPLFRRLGLGSVLGYFTAGLAIGPYGVGLFPNPESVL
HVAELGVVMFLFIIGLEMQPSRLWNLRREIFGLGVAQVALCGTLLTGVGYTYGLPLPAAF
IAGMGFVLSSTAVVMQMLNERGETSTPQGQQAVSILLLEDLAIVPLLAVVALLAPASASQ
GSGWLSVGIAAAAVAGLVVAGRYLLNPMFRLLALAHAREVMTAAALLVVLGSALTMQLSG
LSMAMGAFLAGVLLSESSFRHQLEADIEPFRGILLGLFFLAVGMSLDLGVIARNWVLIGF
AVIAFMSVKALGIFIVAKVSGSRTREAVTRVALFSQGGEFAFVLYAAAASASIFNAQTNA
VVSATVILSMALTPLLVIALDRFLPPEETSLDGVDLAEGLNGRALIIGFGRFGQVASQAL
LARGFSVSIIEVDVELIQAAAGFGFKVHYGDGTRPEILHASGAERAEVILVCVDNRETSN
RIVAVAQEAFPHAKLFVRAYDRGHAMDLIRAGVEYQIRETFESAMAFGTAVLLGMGVSEQ
EAAEIAEDVRRRDAERLDLQVASDIHAGVSLIRGNAPVPTPLTKPKTPGKIHGNVPDDLG
AM