Protein Info for ABIE41_RS03570 in Bosea sp. OAE506

Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1016 TIGR00593: DNA polymerase I" amino acids 23 to 1016 (994 residues), 889.6 bits, see alignment E=1.5e-271 PF02739: 5_3_exonuc_N" amino acids 23 to 184 (162 residues), 150.1 bits, see alignment E=9.7e-48 PF01367: 5_3_exonuc" amino acids 205 to 301 (97 residues), 87.5 bits, see alignment E=1.5e-28 PF01612: DNA_pol_A_exo1" amino acids 410 to 600 (191 residues), 104.7 bits, see alignment E=1e-33 PF00476: DNA_pol_A" amino acids 633 to 1014 (382 residues), 524.4 bits, see alignment E=3.5e-161

Best Hits

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1016 amino acids)

>ABIE41_RS03570 DNA polymerase I (Bosea sp. OAE506)
MSETAKTAAGTAAAPALKPGDHLFLVDGSNFIFRAYFQSINQDRKYNVRSDGLPSGAVRL
FATKLFQFVREGVLGVRPTHLAIVFDKSENSFRKAIYPAYKGNRSDPPPDLIPQFPLMRE
AVRAFGLLPVEQDVYEADDLIATYAKQAREAGADVLIVSADKDLMQLVRPGVAMYDPASG
DAKKGAGFRAERRIGEPEVVEYFGVMPDKVTDVQALAGDATDNVPGAPGIGIKTAAQLIG
EYGDLDTLLARAGEIKQPKRRETLTNPEIVEKIRISHKLVSLVDDVVVETPLEDLTLGQP
DPVRLVAFLKAMEFTTITKRVGEAYEADVAAIDADADLAPGGTRAAELKALHVGADAAGE
APSVAEMARAAVTQPVSTTGGEGWLKPADLAAARKGEALAAKIDRTGYDCVRDLASLERW
VAAAFEAGHVAIDTETSAIDPMQADLVGISLAVAPGKACYIPLQHRGGTDLFGGGMLEGQ
IPLDQALAALKPLLTDPGVVKIGQNLKYDLVLLKRYGVDVAPIDDTMLISYALDAGNNSH
GMDRLSELHLGHETITFGQVAGTGKAQVTFDKVALDKATDYAAEDADVTLRLWRTLKPRL
AAEGRTTVYETLERPLIAVLARMEAHGISIDRQILSRLSGDFAQSLARLEDEIYEIAGEK
FTIGSPKQLGDILFGKMGLSGAKKTATGQWATGAGVLEELAEQGHPLPSKILEWRQLSKL
KSTYTDSLPAYVNPQTQRVHTSFALAATTTGRLSSSEPNLQNIPIRTEAGRKIRTAFVAE
KGYKLVSADYSQIELRLLAHIAEIPQLRQAFADGIDIHAMTASEMFGVPVQGMPSEVRRR
AKAINFGIIYGISAFGLANQLGIGREEASAYIRKYFERFPGIRDYMEQTKTFVRANGHVE
TIFGRICHFPAVASKNPSERAFVERQAINAPIQGSAADIIRRAMIRMEDALAAARLDVRM
LLQVHDELVFEVPDAQVEAALPVITKVMVEAPHPAVQLRVPLQVDARAAGNWDEAH