Protein Info for ABIE40_RS12140 in Rhizobium sp. OAE497

Annotation: AGE family epimerase/isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF07221: GlcNAc_2-epim
  • amino acids 43 to 396 (354 residues), 401.4 bits, E=1.9e-124

Best Hits

KEGG orthology group: None (inferred from 89% identity to rle:RL3363)

Predicted SEED Role

"N-acylglucosamine 2-epimerase (EC 5.1.3.8)" in subsystem Sialic Acid Metabolism (EC 5.1.3.8)

MetaCyc Pathways

• N-acetylneuraminate and N-acetylmannosamine degradation II (1/3 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.8

Protein Sequence (419 amino acids)

>ABIE40_RS12140 AGE family epimerase/isomerase (Rhizobium sp. OAE497)
MASANGSSGLGNWTTRAYHRNWLLAQANGLFDFFQHQSINPKGGFYDLDDQGKPLDAEGQ
VRSIHIAARAVHCFAAGTLLGRPGASDVVDHGMDYLWNHHRDRKNGGYFWSLDNNGPVDS
NKQGYGHAFVLLAASSAKTIGHPLADGMLADITEVLNTRFWEARHGAIAEEFTADWQPLD
GGNYRGQNSNMHLTEALMAAFEATGDREYLTKAESIADLVIRRAAGSVGWRVAEHFGADW
SLDKNYYHPNEMFRPAGTTPGHSLEWARLILQLWVLGGKKLDWLPDAAKGLFSQSMALGW
DNDKGGFFYTLDWDDKPAKRNKLWWPACEAAAAAHFLNEHLPSDFHEESYRKVWNVIERC
FIDHENGGWHEELTEDLVPSHSLFPGKGDIYHALQACLIPLFPATGSITKGIIEAGGKL