Protein Info for ABIE40_RS03725 in Rhizobium sp. OAE497

Annotation: monocarboxylate uptake permease MctP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 491 transmembrane" amino acids 7 to 28 (22 residues), see Phobius details amino acids 50 to 75 (26 residues), see Phobius details amino acids 81 to 103 (23 residues), see Phobius details amino acids 130 to 151 (22 residues), see Phobius details amino acids 162 to 181 (20 residues), see Phobius details amino acids 190 to 209 (20 residues), see Phobius details amino acids 240 to 258 (19 residues), see Phobius details amino acids 278 to 298 (21 residues), see Phobius details amino acids 322 to 350 (29 residues), see Phobius details amino acids 371 to 394 (24 residues), see Phobius details amino acids 400 to 419 (20 residues), see Phobius details amino acids 427 to 446 (20 residues), see Phobius details amino acids 460 to 482 (23 residues), see Phobius details PF00474: SSF" amino acids 44 to 434 (391 residues), 65.5 bits, see alignment E=2.2e-22

Best Hits

Swiss-Prot: 92% identical to MCTP_RHIL3: Monocarboxylate transport permease protein (mctP) from Rhizobium leguminosarum bv. viciae (strain 3841)

KEGG orthology group: K03307, solute:Na+ symporter, SSS family (inferred from 92% identity to rle:pRL100404)

Predicted SEED Role

"Acetate permease ActP (cation/acetate symporter)" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (491 amino acids)

>ABIE40_RS03725 monocarboxylate uptake permease MctP (Rhizobium sp. OAE497)
MTTEINGTALSVFIFFFILVTVMGFVAARWRKPETLAHIDEWGLGGRSFGTWITWFLVGG
DFYTAYTVIAVPALVYTVGAYGFFALPYTIVVYPFVFMVMPVLWKRAKDFGYVTAGDVVH
GQYGSRGLELAVAATGVIATMPYIALQLVGMTAVLKALGLHGELPLAIAFIVLALYTYSA
GLRAPALIAFVKDIMIYVVVIAAVALIPSKLGGYANVFASADAAFQAKGSGNLLLGGNQY
VAYATLALGSALAAFMYPHTLTGIFASNSGNTIRKNAVLLPAYTLLLGLLALLGYMGHAA
NLQLESPNDVVPALFETLFSSWFAGFAFAAIAIGALVPAAVMSIGAANLFTRNFWKAYVN
PEVSDAGEAKVAKITSLVVKIGALLVILFLPTQFALDLQLLGGIWILQTLPALVFGLYTN
WFRAPGLLAGWFIGFFGGTFLVWINGLKPLQPITLGETSFTIYIGLLALVANILVAVVVN
VVTPAKAVVRA