Protein Info for ABID97_RS28035 in Variovorax sp. OAS795

Annotation: fumarylacetoacetate hydrolase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 264 PF10370: Rv2993c-like_N" amino acids 1 to 51 (51 residues), 40.7 bits, see alignment 3.7e-14 PF01557: FAA_hydrolase" amino acids 57 to 254 (198 residues), 226 bits, see alignment E=4.6e-71

Best Hits

Swiss-Prot: 49% identical to Y2225_ARCFU: Uncharacterized protein AF_2225 (AF_2225) from Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

KEGG orthology group: None (inferred from 59% identity to rec:RHECIAT_CH0002323)

Predicted SEED Role

"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (264 amino acids)

>ABID97_RS28035 fumarylacetoacetate hydrolase family protein (Variovorax sp. OAS795)
MHIARYALDECVHYGIIENEGSIARLESSPLEGLKRSGAIDSLAAVRLLAPIAQPRVFGL
GYNYVAHSHEVGKAVPQRPVLFMKPSTSVIGPDASIVYPDDGQNIHFEGELTVVIGRKAR
HVSAADALDHVLGYTCGNDVSDRVLQRSESEFGCLLAGKGYDTFAPMGPVIATGLDPSRI
GIVTRVNGAVRQNGTTADLLFSVPEIIAYLSRYMTLLPGDMIMTGTPAGVGPIQVGDTIE
VEIEGIGILRNGVVAEDRGSAPRG