Protein Info for ABID97_RS26560 in Variovorax sp. OAS795

Annotation: dicarboxylate/amino acid:cation symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 transmembrane" amino acids 15 to 33 (19 residues), see Phobius details amino acids 49 to 70 (22 residues), see Phobius details amino acids 82 to 105 (24 residues), see Phobius details amino acids 150 to 170 (21 residues), see Phobius details amino acids 190 to 213 (24 residues), see Phobius details amino acids 228 to 250 (23 residues), see Phobius details amino acids 266 to 284 (19 residues), see Phobius details amino acids 304 to 323 (20 residues), see Phobius details amino acids 332 to 351 (20 residues), see Phobius details amino acids 357 to 380 (24 residues), see Phobius details PF00375: SDF" amino acids 15 to 407 (393 residues), 386 bits, see alignment E=1e-119

Best Hits

Swiss-Prot: 88% identical to DCTA2_CUPMC: C4-dicarboxylate transport protein 2 (dctA2) from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

KEGG orthology group: K11103, aerobic C4-dicarboxylate transport protein (inferred from 98% identity to vpe:Varpa_0732)

MetaCyc: 73% identical to C4 dicarboxylate/orotate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-121; TRANS-RXN-121A; TRANS-RXN-121C; TRANS-RXN-122A; TRANS-RXN0-451; TRANS-RXN0-517; TRANS-RXN0-553

Predicted SEED Role

"Aerobic C4-dicarboxylate transporter for fumarate, L-malate, D-malate, succunate" in subsystem Pyruvate metabolism I: anaplerotic reactions, PEP

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (448 amino acids)

>ABID97_RS26560 dicarboxylate/amino acid:cation symporter (Variovorax sp. OAS795)
MDQPSVAPKPFYKSLYFQVITAIVLGVLLGHFYPDTGASMKPLGDGFIKLIKMIIAPIIF
CTVVVGIAGMEDMKKVGKTGGLALLYFEIVSSIALVVGLVIINIVRPGAGMNVDVSQLDA
KSVAAYTGPGKMQSTTDFLLNVIPNTVVDAFAKGEILQVLLIAVMFGFALHKFGGRGTLV
FDVIEKGSHVLFVIVGYIMKVAPIGAFGAMAFTIGKYGVSSLLQLGQLMATFYLTCLLFI
FVVLGGIARFHGFSIWKFIKYIKEELLIVLGTSSSESVLPRMMAKLENLGAKKSVVGLVV
PTGYSFNLDGTSIYLTMAAVFIAQATNTDMTIMQQITLLAVLLLTSKGAAGVTGSGFIVL
AATLSAVGHVPVAGLALILGIDRFMSEARALTNLIGNGVATVVVAKWTDDLDTVRMNRIL
NQETGAESDEPEQVLDATEAHMPASPAR