Protein Info for ABID97_RS23835 in Variovorax sp. OAS795

Annotation: pyroglutamyl-peptidase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 69% identical to PCP_CUPNH: Pyrrolidone-carboxylate peptidase (pcp) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K01304, pyroglutamyl-peptidase [EC: 3.4.19.3] (inferred from 93% identity to vap:Vapar_4364)

Predicted SEED Role

"Pyrrolidone-carboxylate peptidase (EC 3.4.19.3)" in subsystem ZZ gjo need homes (EC 3.4.19.3)

MetaCyc Pathways

5-oxo-L-proline metabolism (5/6 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.19.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (219 amino acids)

>ABID97_RS23835 pyroglutamyl-peptidase I (Variovorax sp. OAS795)
MAQRTNVLLTGFDPFDREALNPSWEAVRALDGWRCGRATVHARQMPCVFGQAIETLAAAM
DELQPELVLCIGQAGGRAEITPERVAINIDDGRIADNAGRQPIDVPVVPGAPAAYFSTLP
IKAMVRDLRKAGIPASVSNSAGTFVCNHIFYGLMHRMAAVPVPGQRGGFIHIPYLPEQAA
RFPGLPSMSLATMVEGLRVAVATALAVEKDVAETGGQLH