Protein Info for ABID97_RS23305 in Variovorax sp. OAS795
Annotation: diaminopimelate decarboxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 54% identical to DCDA_PSEAE: Diaminopimelate decarboxylase (lysA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG orthology group: K01586, diaminopimelate decarboxylase [EC: 4.1.1.20] (inferred from 94% identity to vap:Vapar_1136)Predicted SEED Role
"Diaminopimelate decarboxylase (EC 4.1.1.20)" in subsystem Lysine Biosynthesis DAP Pathway (EC 4.1.1.20)
MetaCyc Pathways
- aspartate superpathway (24/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
- L-lysine biosynthesis I (9/9 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- L-lysine biosynthesis III (6/7 steps found)
- L-lysine biosynthesis VI (6/7 steps found)
- L-lysine biosynthesis II (6/9 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.20
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (427 amino acids)
>ABID97_RS23305 diaminopimelate decarboxylase (Variovorax sp. OAS795) MTTNASPLPGHPHVVQRDDALHVEGVSLDALAREHGTPLFVYSKQWMLDALAAYQRGFEG RDALICYAMKANSSLGVLRVFAEAGCGFDIVSGGELARVLAVGADPSKIIFSGVGKSRGE MRQALAAGIACFNVESEAELDVLNEVALAEGARAPISIRINPNVDPKTHPYISTGLKGNK FGIAHDRAVEAYRHAARLPGLEVVGIDCHIGSQITEASPYLDACDRILDLVEAIEAAGVP IHHLDFGGGLGIDYNGEVPPKADALWQQLLARLDARGFGQRKLVIEPGRSLVGNAGVCVT EVLYTKPGEDKNFCIVDAAMNDLPRPAMYQAFQKIVPLRIRAGGATTYDVVGPVCESGDW IGRDRALNVVAGDLLAVLSAGAYCMSMASNYNTRGRAAEVLVSGQSATLIRRRETMEDQL RSEQVEG