Protein Info for ABID97_RS23250 in Variovorax sp. OAS795

Annotation: deoxyguanosinetriphosphate triphosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 376 TIGR01353: putative dGTPase" amino acids 25 to 370 (346 residues), 294.5 bits, see alignment E=9e-92 PF01966: HD" amino acids 63 to 197 (135 residues), 51.9 bits, see alignment E=8.9e-18 PF13286: HD_assoc" amino acids 284 to 368 (85 residues), 99.3 bits, see alignment E=1.5e-32

Best Hits

Swiss-Prot: 64% identical to DGTL1_RALSO: Deoxyguanosinetriphosphate triphosphohydrolase-like protein (RSc2968) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K01129, dGTPase [EC: 3.1.5.1] (inferred from 92% identity to vap:Vapar_1147)

Predicted SEED Role

"Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1)" in subsystem Purine conversions (EC 3.1.5.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.5.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (376 amino acids)

>ABID97_RS23250 deoxyguanosinetriphosphate triphosphohydrolase (Variovorax sp. OAS795)
MNLAAYACHPAQSRGRRHAEPPAPTRDAFQRDRDRIVHSTAFRRLVYKTQVFLNHEGDLF
RTRLTHSLEVAQLGRSIARALRINEDLVEAIALAHDLGHTPFGHAGQDSLNACMEGHGGF
EHNLQSLRVVDALELRYPQYDGLNLSFETREGILKHCSRANAERLEAAEPGGVARRFLDR
TQPGLEAQLCNLADAIAYNAHDIDDGVRSGLITVEQLGEVPLFERYRREALAEHPHLEGR
RVLYETIRRMLSAQVYDVIDATRAAIEAAGPADAKGVRHAAPLVAFSDAMQAQSSELKGF
LFRNLYRHPQVAQTTEQAQQVVRELFEAYLERPGEMPVAYAERRDRYRSVADYIAGMTDR
FAMREHERLTGRRGIA