Protein Info for ABID97_RS22120 in Variovorax sp. OAS795

Annotation: xanthine dehydrogenase molybdopterin binding subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02965: xanthine dehydrogenase, molybdopterin binding subunit
  • amino acids 42 to 814 (773 residues), 1275 bits, E=0
• PF01315: Ald_Xan_dh_C
  • amino acids 57 to 159 (103 residues), 71.4 bits, E=1.2e-23
• PF02738: MoCoBD_1
  • amino acids 199 to 431 (233 residues), 272.4 bits, E=4.2e-85
• PF20256: MoCoBD_2
  • amino acids 458 to 743 (286 residues), 332.1 bits, E=4.9e-103

Best Hits

KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 96% identity to vap:Vapar_3906)

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• ureide biosynthesis (5/7 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (2/7 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (2/10 steps found)
• theophylline degradation (1/9 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Protein Sequence (816 amino acids)

>ABID97_RS22120 xanthine dehydrogenase molybdopterin binding subunit (Variovorax sp. OAS795)
MNKPIDARLLQPSEAFSDYLKNTAARIDQGAESLAHDQGARVGISRPHESAHLHVAGEAT
YIDDIPEITGTLHCALGLSPAANGRVTALSLDAIRAMPGVVSVLTADDIPGTNDCGSIIH
DDPILLPVNEGGEIRYLGQPVFAVIAETREAARRAASKAREAMTIEAEPPVLTPQDAHAR
GQYVVPPMHIVRSGGAANEGDEAAVRAAIAKAPHRHKATLDVGGQEQFYLEGQISYAIPK
EGGALHIHCSTQHPSEMQHLVAHALHLQSNEVHVECRRMGGGFGGKESQSALFACVAAVA
ASKLRRPVKLRLDRDDDFMITGRRHCFWYEYEVGYDDEGRILGAEITMVSRAGHSADLSG
PVMTRALCHFDNAYWLPNVAMHGYSGKTNTQSNTAFRGFGGPQGAIAVENIMDSVARELK
RDPLDVRRINFYGKAENNVTPYRQTVTDNIVHELVAELETSSDYRARREEIAAFNAKSTV
LKRGLALAPLKFGISFNVKHFNQAGALVHVYTDGSILVNHGGTEMGQGLNTKVAQVVAHE
LGVSFERVRVTATDTTKVANTSATAASTGADLNGKAAQDAARQIRERLAESAAERHGGKA
AEVRFANDKVEVNGRSLAFSTVVGEAYLDRKQLWSDGFYATPGLSWDKDKMQGRPFYYYA
YGAAVSEVIVDTLTGEWKLLRADILHDAGKSLNPAVDIGQVEGAFIQGMGWLTTEELVWH
PKTGLLTTHAPSTYKIPTANDCPPVFNVRLFEGQNFEDSIHRSKAVGEPPLLLPFSVFFA
IRDAVSAAGGHRVDPPLQAPATSESILRAVTAVQSA