Protein Info for ABID97_RS22110 in Variovorax sp. OAS795

Annotation: NCS2 family permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 transmembrane" amino acids 52 to 73 (22 residues), see Phobius details amino acids 85 to 106 (22 residues), see Phobius details amino acids 115 to 134 (20 residues), see Phobius details amino acids 138 to 159 (22 residues), see Phobius details amino acids 171 to 192 (22 residues), see Phobius details amino acids 204 to 222 (19 residues), see Phobius details amino acids 229 to 247 (19 residues), see Phobius details amino acids 272 to 296 (25 residues), see Phobius details amino acids 318 to 340 (23 residues), see Phobius details amino acids 352 to 369 (18 residues), see Phobius details amino acids 376 to 396 (21 residues), see Phobius details amino acids 414 to 437 (24 residues), see Phobius details amino acids 449 to 466 (18 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 55 to 425 (371 residues), 205.4 bits, see alignment E=6.3e-65

Best Hits

Swiss-Prot: 53% identical to Y326_METJA: Putative permease MJ0326 (MJ0326) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 95% identity to vap:Vapar_3904)

MetaCyc: 50% identical to adenine:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-447

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (468 amino acids)

>ABID97_RS22110 NCS2 family permease (Variovorax sp. OAS795)
MNRFEEVPKVTDSRASGSTEAARTRSAAGTAPYANANWLERMFKLTEHNTTVRTEVIAGL
TTFLTMAYIIFVNPSILGDAGMPKGAVFVATCLIAALGTLIMGLYANYPIAMAPGMGLNA
YFAYVVVLGMGYTWQVALGAVFISGCLFLIVTVTGLRELFIQGIPHSLRTAITVGIGMFL
ALIALKSAGVVAASPATFVTLGDLHSAPVVLATLGFLVIVVLDRLKVRGAILIGIMLVTV
LSFFFGGNKFHGVFDAPPSIAPTFMQLDILGALKGGILNVVLVFFLVEMFDATGTLMGVA
KRAGLLVPGKMERMNKALLADSGAIFAGSLLGTSSTTAYVESAAGVQAGGRTGLTAVVVA
VLFLACLMISPLAGSVPAYATAPALLFVGCLMLRDLVELEWEDTTEVIPAVVTALAMPFT
YSIANGLAFGFITYAVLKLFTGRAREVHAMVWVIAAIFLFKFAYVGGH