Protein Info for ABID97_RS21300 in Variovorax sp. OAS795

Annotation: phosphogluconate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 608 TIGR01196: phosphogluconate dehydratase" amino acids 4 to 606 (603 residues), 905.4 bits, see alignment E=7e-277 PF00920: ILVD_EDD_N" amino acids 68 to 383 (316 residues), 319.4 bits, see alignment E=2.6e-99 PF24877: ILV_EDD_C" amino acids 409 to 604 (196 residues), 184.9 bits, see alignment E=1.1e-58

Best Hits

KEGG orthology group: K01690, phosphogluconate dehydratase [EC: 4.2.1.12] (inferred from 95% identity to vap:Vapar_3708)

Predicted SEED Role

"Phosphogluconate dehydratase (EC 4.2.1.12)" in subsystem Entner-Doudoroff Pathway (EC 4.2.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (608 amino acids)

>ABID97_RS21300 phosphogluconate dehydratase (Variovorax sp. OAS795)
MSTHPTVVDVTERIRERSRGPRSAYLERLREIRNRDRGSDRMGCANVAHAVASIPANDKF
RVVTERAPNIGIVTAYNDMLSAHAPYQGYPDIIKQEARSLGATAQVAGGVPAMCDGVTQG
TPGMELSLFSRDVIAMGTAVALTHDMFDGALLLGVCDKIVPGLLIGALHFGHLPTVFVPA
GPMPSGLSNGEKSKVREQAAQGLVGRQGLLDAEMAAYHTVGTCTFYGTANSNQMLLEAMG
LHVPGTAFIQPGDAMRETLTREAVRTVLGKASEAKFNCPPIGEVVDERCIVNAMVALLAT
GGSTNHLIHWVAVARSAGIVIDWDDFSRLSDVIPLLTRVYPNGSADVNAFQAAGGPGFVI
GELLDAGLMHADVLTVRAGGLREFANVPSLMDGKRLAWHSAAPSKDESVARPVQSPFSAT
GGLKLLNGNLGRSVIKVSSVPDDRHVIEAPARVFDSQAALHQAFTAGELDRDVVCVVRWQ
GPQANGMPELHKLTPPLSVLQGKGFRVALVTDGRMSGASGKVPAAIHVSPEAAAGGPLAK
VRDGDVIRLDAVAGTLAVLVPDDEWAERGIATLPEAKRIADGHGLGRELFAGMRRNALTA
EEGACSWL