Protein Info for ABID97_RS20585 in Variovorax sp. OAS795

Annotation: bifunctional protein-serine/threonine kinase/phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 566 transmembrane" amino acids 541 to 564 (24 residues), see Phobius details PF13672: PP2C_2" amino acids 34 to 193 (160 residues), 32.4 bits, see alignment E=1.4e-11 PF00069: Pkinase" amino acids 280 to 513 (234 residues), 101.6 bits, see alignment E=1e-32 PF07714: PK_Tyr_Ser-Thr" amino acids 283 to 509 (227 residues), 62.3 bits, see alignment E=9.1e-21

Best Hits

KEGG orthology group: None (inferred from 95% identity to vap:Vapar_3527)

Predicted SEED Role

"Serine/threonine protein kinase (EC 2.7.11.1)" (EC 2.7.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.11.1

Use Curated BLAST to search for 2.7.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (566 amino acids)

>ABID97_RS20585 bifunctional protein-serine/threonine kinase/phosphatase (Variovorax sp. OAS795)
MSFEVDIGYSSQRGPRDVNEDFAGAVNAPPGDESRGLIAAIADGVSTGGRGLEASQTTVM
GLLADYFATPDTWEPTAALDRLVAAQNAWLADHNRRRQGGGTALTTLTALVLHGQSYTLA
HVGDTRAWRVRTDGEPAMLLTQDHAFEHPDMRSRLTRAIGLDDQVRVDYAQGDVRVGDCF
VLTSDGVHGVLKPQRLAELALQGGAEDASEALVRAALEAGTRDNATALVIRVVGLDARQL
DDELGDGRRLAPPPLLKVGDALDGYVVTGLVADTGVHLLYQARNAATRELVALKTLHPSR
ASDPQERAMLAHEAWLGQRVGSGGFVRVHERAENASALYIVFDWHGGRTLEQMRKSGARG
TVAEVVGAAIEVTKALGRLHRHGVVHRDIKPGNLHLGEDGRWRILDLGVALSGREGAAQR
ELHAGTPSYINPEQWEGAHADPGSDLFALGATLYQWLCGHLPYGEIEPYQVARYRRDPVA
LSRLRPDVPVWLDHLVRKAVARDPKERFETAEEMLLALERGASRPVSAPAATPLIRRDPA
ALYKIALAVSLLFNALLVVWLLFLPR