Protein Info for ABID97_RS19690 in Variovorax sp. OAS795

Annotation: TIM barrel protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01261: AP_endonuc_2
  • amino acids 18 to 260 (243 residues), 135.3 bits, E=6e-43
• PF14696: Glyoxalase_5
  • amino acids 296 to 429 (134 residues), 100.3 bits, E=2.3e-32
• PF00903: Glyoxalase
  • amino acids 446 to 568 (123 residues), 29.4 bits, E=1.8e-10

Best Hits

KEGG orthology group: K00457, 4-hydroxyphenylpyruvate dioxygenase [EC: 1.13.11.27] (inferred from 90% identity to vap:Vapar_3320)

Predicted SEED Role

"4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)" in subsystem Aromatic amino acid degradation or Homogentisate pathway of aromatic compound degradation or Plastoquinone Biosynthesis or Tocopherol Biosynthesis (EC 1.13.11.27)

MetaCyc Pathways

• L-tyrosine degradation I (5/5 steps found)
• plastoquinol-9 biosynthesis I (1/3 steps found)
• superpathway of plastoquinol biosynthesis (2/5 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (4/9 steps found)
• vitamin E biosynthesis (tocopherols) (1/7 steps found)

KEGG Metabolic Maps

• Phenylalanine metabolism
• Tyrosine metabolism
• Ubiquinone and menaquinone biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.13.11.27

Use Curated BLAST to search for 1.13.11.27

Protein Sequence (630 amino acids)

>ABID97_RS19690 TIM barrel protein (Variovorax sp. OAS795)
MHRSIATVSLSGTLRQKLEAVAAAGFDGIELFEADFVNFKGTAAELGRIAADLGLSIDLY
QPFRDFEAMPEPQFRRSLERAERKFDLMEAMGAPMVLCCSNTSPLAIDDPALAAAQLHEL
AERAARRNLRVGFEALAWGRFTSLYGQAWNIVREAAHPNLGLILDSFHTLSLKDDPAGIA
AIPGDRIFFLQMADAPLLAMDVLQWARHHRSFPGQGDLDVIGFFAQVLRAGYTGPLSLEI
FNDIFRETPNRRTAVDAMRSLLYLESEARLRVAAAAAAPAHARPVALFSPPAAPALSGLS
FIEFAADEASALTLGTLLGQLGFRRAGRHRSKAVVLYRQGEINLIVNAQPDSFARSRFDA
HGTSVCALGVRCADPQAAVDRATAMRSQRHDSPVGPDELRVPAIVAPGGNLIHFVAESLG
TNGLHEADFILEEQAPDAAPDVGLMRIDHVALGLAVDQLDTWVLFTRAVLGLEPGESLEL
ADPFGLIRSRGVANADRSVRLVLNVSLSQRTRTARTLSVTGGGAVHHIALCCDDIFDSVA
RLRAAGTRFVPISDNYYDDLATRIDLDPALLARLRASGVLFDRSPAGDYLHIYTENIEGG
LFFELAQRTAGYDAYGALNAPARMASQAQA