Protein Info for ABID97_RS19085 in Variovorax sp. OAS795

Annotation: amino acid adenylation domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 193 to 537 (345 residues), 281.2 bits, E=6.2e-87
• TIGR01733: amino acid adenylation domain
  • amino acids 214 to 611 (398 residues), 400.8 bits, E=3.1e-124
• PF13193: AMP-binding_C
  • amino acids 595 to 669 (75 residues), 45.3 bits, see alignment (E = 7.1e-15)
• PF00550: PP-binding
  • amino acids 698 to 762 (65 residues), 44.2 bits, see alignment (E = 9.5e-15)
  • amino acids 1725 to 1791 (67 residues), 41.2 bits, see alignment (E = 8e-14)
• PF00109: ketoacyl-synt
  • amino acids 799 to 1047 (249 residues), 230.4 bits, E=1.4e-71
• PF02801: Ketoacyl-synt_C
  • amino acids 1055 to 1173 (119 residues), 131.5 bits, 8.2e-42
• PF16197: KAsynt_C_assoc
  • amino acids 1176 to 1288 (113 residues), 61.8 bits, 4.1e-20
• PF22621: CurL-like_PKS_C
  • amino acids 1237 to 1300 (64 residues), 71.5 bits, see alignment (E = 2.4e-23)
• PF22336: RhiE-like_linker
  • amino acids 1241 to 1301 (61 residues), 47.9 bits, see alignment (E = 5.2e-16)
• PF00698: Acyl_transf_1
  • amino acids 1323 to 1612 (290 residues), 182.1 bits, E=1e-56
• PF00202: Aminotran_3
  • amino acids 1998 to 2353 (356 residues), 163.9 bits, E=2.6e-51

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• fatty acid biosynthesis initiation (mitochondria) (2/4 steps found)
• fatty acid biosynthesis initiation (plant mitochondria) (1/4 steps found)
• mycobactin biosynthesis (3/11 steps found)
• pederin biosynthesis (2/14 steps found)
• bryostatin biosynthesis (2/19 steps found)
• mupirocin biosynthesis (1/26 steps found)
• corallopyronin A biosynthesis (2/30 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Protein Sequence (2442 amino acids)

>ABID97_RS19085 amino acid adenylation domain-containing protein (Variovorax sp. OAS795)
MELETEDARRWAGWIAATSQLPDTPFAAAWLLLQTRWLGMQEPALHAAQVNGTTGTVAIF
VPFEPGQVPGDWLALIDAQRRTATAAPAEAAPASLWLNGNAAPGLQAPLQLWLSTASGSP
RLHADAAATLLDAASASQLLAAIADTAAHLMDGGDARLGDIRTAPAADREQQLSRWNAAV
SALEPGLTVAGMFARQAAAAPDATALVQGDARMSYGELDRHSDALAHRLQHLGVRAGDSV
GLVLERSMDAVVAQLAVLKAGAAYVPVPTDFPPERIAYMLDEAEARQVIATSAQRHLVPG
SRPALLLDEVHGTELAPWHAPAVDGESVAYVMYTSGSTGTPKGIEICHRAILRLVIGVDY
ADLAPGRAMLHAAPLGFDAATLEIWGPLLNGGCCVIHGERVPTGAGLAATIARHGVHTAW
LTAALFNAVVDDDPAHLSGLRHLITGGEALSVPHVRRALSALPQLTLSNGYGPTECTTFA
ATYRIPHALPAELRSVPLGRPIKDTVLRVLSPSMALLPTGLIGELCIGGHGLARGYLGQP
TLTEERFVPDPFGRAGERLYRTGDLARWLPDGTIEFIGRRDGQVKIHGHRIETGEVEMAI
LAHPAVRACAVVARPDADGQLRLVAYLVARSQKISWDALRTHLAARLPAALLPSAQVWLD
ALPVTANGKLDRKALPEPLVDRPELAQPFEEARNATEQRVCEAFARALHLGKVGRNDNFF
DLGGDSLRVLQVLAELQRDSAQPLSTNLFFRHPTPSAMAAALEPAEGEAAPTSSTATRAT
TAVSRASVPTSDNGDLSDAVALIATAGRFPGAADVEQFWDNLVAGRDTISFFDDETLDAG
VSEALRTDPAYVRARGVIEGIENFDAAFFGIGPKEAALMDPQQRVFLEICWECLERAGYV
PDAAPGPVGVYAGMYNASYFQRHVSTRPDLIEAVGEFQVMLANEKDYITTRVANRLNLTG
PAVSVHTACSTSLVAVAHAFHALRTGQCYMALAGGASVTCPTRSGYLYQEGSMLSPDGRT
RSFDAQAQGTVFSDGAAVVLLKRLSDAQADGDTIYAVLRSACVNNDGGSKASFTAPSVDG
QAAVIRAALAAANVDARSISYVEAHGTATPMGDPVEVEALTCAYGEHTDALGYCTLGSLK
SNVGHMVTAAGAAGLIKTALSLHHEVIPPTAHFSAPNPAIDFARTPFYVSPSLQPWPRAR
EPRRAGVSSFGVGGTNAHVVVEEAPVRPASTCAKGPQVLPLSARSEAALAVATEQLAAHL
EATPGVPLADVAYTLGVGRKAHAFRRAVVASNAAEAVAALRGNDGPWRVSGRIDARAPQP
VLMFPGQGAQYPGMGKNLHANDPVFAAAFDTCIKAFGDAVDFDLRERMFGTDAEALVPTA
VTQPAIFTLEYALARRLLSLGARPHALIGHSVGEFVAAVLAGVMRLEDAARLVARRGALM
QAQPAGAMLSVRLGATELAARLGPSLSLAADNGPTACVVAGPFEAIEALQAELQKDDIAA
RPLQTSHAFHSAMMDAAVVPFEALVGEVALHAPAIPVFSTLTGRLLEDSEATSPAYWARH
LRSTVQFSPAVRSAMAHAARPLFIEVGPRNTLATLVRQHGAAEVMSLLHGEPADEARTLR
LALARLWTCGADVELSRLAVRAGAQRVRLPTYPFERKRFWVDIAASAATPATVPAVSPPE
APAVAQPSPAPFVPPLLLEPIVTAAASPPLPSSASTPAAEPMGARLRSLFEDISGIDMAQ
ADGHAAFGELGLDSLTLTQVATQIKKRFKVNLSFRQLMESYRNFDTLAAFLQESLPPEAA
VVAPAAAVPAAPAAVSPSMPVAMPAAAQASIAVQPAAYLPPINAALHAGGIGIGATPLAQ
LVAQQMELMRQQLALLSGMTADTVPATSALPSQPAPTAGVAAQPAVVPVAQPAADDGGAP
KEPVRYDVTKAFGAIARIHTQRTAEPSGRQKARLATFMRRYVQRTRKSKEFTEANRPHMA
DPRVVNGFRPLTKEITYQIVIERSKGSKLWDLDGNEYVDALNGFGMNMFGWQPDFVQEAV
KKQLDAGYEIGPQHPLAADVTRLICELTGNDRAALCNTGSEAVMAALRIARTVTGRSTVV
VFTGSYHGTFDEVLVRAGRGAKGLSAAPGVMSGMFGDIRVLDYGTPEALAFIRENAEDLA
AVLVEPVQSRRPDLQPREFLHEVRAITEKQGAALIFDEVITGFRTALGGAQELFGVRADL
ATYGKVIGGGFPVGVIAGKRAFMDALDGGAWQYGDDSIPGVGVTYFAGTFVRHPLALAAA
KASLEHLKEAGPALQSGLTANTAAMAGELTAWCAEVGAPIAVRHFASLWRVSWLEDHPLQ
DLLFAMMRSRGVHILDNFPCFLTSAHSAEDIATISRVFKESVAEMQESGFLPRRATVITG
FDYRKAHEEDGSVLARDIDGQPFWYVPDTSSPSQLINGKAAA