Protein Info for ABID97_RS18620 in Variovorax sp. OAS795
Annotation: 3-oxoacyl-[acyl-carrier-protein] synthase III C-terminal domain-containing protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 53% identity to pla:Plav_3069)Predicted SEED Role
"Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis or Ketoisovalerate oxidoreductase or Leucine Degradation and HMG-CoA Metabolism (EC 2.3.3.10)
MetaCyc Pathways
- ketogenesis (4/5 steps found)
- ferrichrome A biosynthesis (3/5 steps found)
- mevalonate pathway I (eukaryotes and bacteria) (2/7 steps found)
- mevalonate pathway II (haloarchaea) (2/7 steps found)
- superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (4/10 steps found)
- isoprene biosynthesis II (engineered) (2/8 steps found)
- mevalonate pathway III (Thermoplasma) (2/8 steps found)
- mevalonate pathway IV (archaea) (2/8 steps found)
- superpathway of ergosterol biosynthesis I (6/26 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (24/56 steps found)
- superpathway of cholesterol biosynthesis (6/38 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Butanoate metabolism
- Synthesis and degradation of ketone bodies
- Terpenoid biosynthesis
- Valine, leucine and isoleucine degradation
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.3.3.10
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (491 amino acids)
>ABID97_RS18620 3-oxoacyl-[acyl-carrier-protein] synthase III C-terminal domain-containing protein (Variovorax sp. OAS795) MFGIIGYGGYVPRLRLVRRAAAEANAWYAPQFVNAAKGTRAFANWDEDSITMAVAAARDC LGAADDRSRIASVLLASGTLPFAERLNAGVVCEALTLRDDVQAADVTGSQRAGVSALAQA VAQVRSGGGDVLVLASDNRKTRAASSQELDFGDGAAALQIGRDKVLAEYLGAGTVTVDFV DHFRAAGEDIDYAWEERWVRDEGITKLVPRAVRAALAEAKVEAAQIDHFIFPTTFQKMDQ QLAKACGVRAEAVTDSLASRVGDTGLPHALLLLAHVLERAQPGQHILLAQFGSGAQAMVF RVTDEIRNFRPAKGVSEWIRRGVEETAYTRFLSFKGQLDLERGMRGEQERKTALSTAYRH RSAILGLVAGRCEVTGSVHFPPSRISYDQGKPLQDTQKPYKLAERRGTVLSWSAEFLSFH RSPPHRYGQVDFDGGGRVLMEFTDTGEGEIDAGSAVEMTFRIKDIDDRRGYTRYFWKATP VRAAATEKGSE