Protein Info for ABID97_RS14935 in Variovorax sp. OAS795

Annotation: xanthine dehydrogenase family protein molybdopterin-binding subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 776 PF01315: Ald_Xan_dh_C" amino acids 27 to 146 (120 residues), 102.1 bits, see alignment E=3.3e-33 PF02738: MoCoBD_1" amino acids 165 to 410 (246 residues), 251.7 bits, see alignment E=8.6e-79 PF20256: MoCoBD_2" amino acids 438 to 701 (264 residues), 239.2 bits, see alignment E=1e-74

Best Hits

KEGG orthology group: K03520, carbon-monoxide dehydrogenase large subunit [EC: 1.2.99.2] (inferred from 92% identity to vap:Vapar_2379)

Predicted SEED Role

"Possible hypoxanthine oxidase XdhD (EC 1.-.-.-)" in subsystem Purine conversions (EC 1.-.-.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.-.-.-, 1.2.99.2

Use Curated BLAST to search for 1.-.-.- or 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (776 amino acids)

>ABID97_RS14935 xanthine dehydrogenase family protein molybdopterin-binding subunit (Variovorax sp. OAS795)
MTTESNPTRFGSGHAVRRLEDESLLAGKGRYTDDVTLPGQAHLVFVRSPYPHARIVSIDA
SAAAAMPGVLRVITGAELAEAGVKPLPGAAGFKRADGSDCASPPRFALAHERARFVGEAV
AVVVAETVQQARDAAEAVAVDYEELPMVVDLASATADGAPLLCEEASGNIAAEMRHGSSD
ATTAAFAKAKHVVALDVVNQRVVALTIEPRSVLAAPEAGSERLTIRMSTQMPSGVRDSVC
AAIGLAKEKVRVVVGDVGGGFGMKTGAYPEDIAVAYAALQVKRPVKWVADRSEEFLSSAH
GRDIEARAELALDAGGKILALRIKTHANVGAYATGTGVAIQLLIGPWVQTSVYDIQTIDF
HFKAVLTNTAPTGAYRGAGRPEAIFTIERLMDEAARQTGIDRIALRRRNFIRPEQMPYTN
PMAQTYDTGKFESVMDQALALSDWSGFEARAAESAARGKHRGLGIATFLEWTGGNVFEER
VTVSVQADGVIEVFSAVNAMGQGIATSLAQLAVDAFGVPIEKVRVVLGDTDRGDGFGSAG
SRSLFTGGSAVRIGAERTIDKARELAAQEFEAAVDDVTYTRGVFTVAGTDLALDLFDLAG
KQPEREIFVDSTSTVAGPTWPNGCHICEIELDPPTGEIAVVAYSSVNDVGRVVNPMIVRG
QLEGGAVQGIGQALYEQVVYDKETGQPVTGSLMDYAVPRADIVQSMFQMEMDESTPCVNN
PLGVKGVGELGTIGATPSIVNAVADAFARNGLVNGTPRLHMPLSPSRVWQAMHTAD