Protein Info for ABID97_RS14080 in Variovorax sp. OAS795

Annotation: M3 family metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 682 PF19310: TOP_N" amino acids 29 to 145 (117 residues), 64.5 bits, see alignment E=8.3e-22 PF01432: Peptidase_M3" amino acids 218 to 675 (458 residues), 458.9 bits, see alignment E=2.9e-141

Best Hits

Swiss-Prot: 47% identical to OPDA_ECOLI: Oligopeptidase A (prlC) from Escherichia coli (strain K12)

KEGG orthology group: K01414, oligopeptidase A [EC: 3.4.24.70] (inferred from 96% identity to vap:Vapar_2158)

MetaCyc: 47% identical to oligopeptidase A (Escherichia coli K-12 substr. MG1655)
Oligopeptidase A. [EC: 3.4.24.70]

Predicted SEED Role

"Oligopeptidase A (EC 3.4.24.70)" in subsystem Protein degradation (EC 3.4.24.70)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.24.70

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (682 amino acids)

>ABID97_RS14080 M3 family metallopeptidase (Variovorax sp. OAS795)
MTNPLLDFADLPLFDRIKPEHVAPAVDILLADAEAALQTVTAADFPADWNAISKVLDVAS
ERFSRAWGAVGHLNAVADTPELRAAYNEAMPRVTAFWTRLGSDERLYAKYKAIDVATLNA
EQRQALRNAVRNFVLGGAELQGDAKKRFAEIQERQAELSQKFSENALDATDAFSYYATLG
ELDGVPEDVVGAARAAAEAEGKQGYKLTLKMPCYLPVMQFAKSSPLRETLYRAYVTRASE
LGDPAFDNTALINEILALREEEAKLLGYRNFGELSVVPKMAESPEQVVKFLRDLAAKAKP
YGERDLADLRVFASEQLGIADPQAWDWSYIGEKLKEARYAFSEQEVKQYFPAPKVMAGLF
KIVETLFEVSIRRDSAPTWHPSVEFYRIERAGQKVGQFYLDPSARSAKRGGAWMDDVRAR
WLRPDDAALQTPVAQLVCNFASGVDGKPPLLTHDDVTTLFHEFGHGLHHMLTQVNERDVS
GISGVEWDAVELPSQFMENFCWEWDVLRHMTAHVDTGEPLPRALFDKMTAAKNFQSGLQT
LRQIEFSLFDMLLHTEYQAATAQPGSVLALLGKVRAEVAVMPSPPFSRTPNTFSHIFSGG
YAAGYYSYKWAEVLSADAYAAFEETVGADGQPNIETGRRYRQAILEAGGSRSAMDSFKAF
RGREPQLDALLRHQGMAEAQPA