Protein Info for ABID97_RS11235 in Variovorax sp. OAS795

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 480 PF00171: Aldedh" amino acids 22 to 475 (454 residues), 581 bits, see alignment E=7.6e-179 TIGR01780: succinate-semialdehyde dehydrogenase" amino acids 29 to 473 (445 residues), 717.3 bits, see alignment E=3.9e-220

Best Hits

Swiss-Prot: 68% identical to DAVD_PSEPK: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: None (inferred from 69% identity to pmk:MDS_0285)

MetaCyc: 67% identical to NAD(P)-dependent succinate-semialdehyde dehydrogenase (Pseudomonas fluorescens)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (480 amino acids)

>ABID97_RS11235 NAD-dependent succinate-semialdehyde dehydrogenase (Variovorax sp. OAS795)
MQGLKDPTLFRQQALIGGIWLDAPETITVRNPATGETIGHVPRMSGAATRQAIEAAEAAL
PAWAALTAKRRSELLRNWFERMMAAQDDLALILTTEQGKPLAEARGEVAYGASFIEWFAE
EARRTYGEVIPSASADTRLVALRQPIGVCAAITPWNFPNAMLARKLGPALAAGCTMVVKP
ASQTPFSALAMAVLAEQAGIPPGVINIVTGSASEIAGELTGNPQVRKISFTGSTEVGRQL
MKQSAPTIKKLSLELGGNAPFIVFDDADLDAAVEGAMVAKFRNNGQTCVCANRILVHDAV
YDAFASKLVARVAALRVGNGVAAGVQIGPLIDAKAVQKVEEHIADALAGGAKLAVGGRRL
EGNFFEPAVMTGVTSSMLVAREETFGPLAPLIRFADEDEAVRIANDTEFGLASYIYTRSL
RRSWRIAERLEFGMVGVNTGLISTAEAPFGGIKQSGLGREGSRHGIDDYMELKYVCIGVA