Protein Info for ABID97_RS06640 in Variovorax sp. OAS795

Annotation: glutamine--fructose-6-phosphate transaminase (isomerizing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 626 (625 residues), 778.4 bits, E=2.4e-238
• PF13522: GATase_6
  • amino acids 62 to 189 (128 residues), 60.5 bits, E=2.6e-20
• PF13537: GATase_7
  • amino acids 102 to 207 (106 residues), 52.6 bits, E=6.6e-18
• PF01380: SIS
  • amino acids 308 to 431 (124 residues), 88.3 bits, E=5.7e-29
  • amino acids 479 to 606 (128 residues), 77.9 bits, E=9.5e-26

Best Hits

Swiss-Prot: 73% identical to GLMS_BORPA: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 98% identity to vap:Vapar_1001)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (10/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Protein Sequence (626 amino acids)

>ABID97_RS06640 glutamine--fructose-6-phosphate transaminase (isomerizing) (Variovorax sp. OAS795)
MCGIVGAASHRNIVPVLVQGLQRLEYRGYDSCGVAVHAGGLTRARTTSRVADLVTQVRED
HVEGLTGIAHTRWATHGAPAVHNAHPHFSHGPGADAQGTRPGRIGLVHNGIIENHESLRA
ALEARGYVFESQTDTEVIAHLVDSLYDGDLFEAVKAAVLQLHGAYAIAVICRDEPQRVVG
ARAGSPLILGAGKEGGENFLASDAMALAGVTDQIVYLEEGDVVDVQPGKYWIVDRHHKPV
ERQVRTVQAHSGAAELGPYRHYMQKEIFEQPRAIGDTLEGVAGIVPELFDGIGQDGATGA
SAHRVFKDIDKILILACGTSYYSGCTAKYWLEGIAKISTQVEIASEYRYRESVPDPRTLV
VTISQSGETADTLAALKHARSLGMEQTLTICNVATSAMVRECKLAYITRAGVEIGVASTK
AFTTQLAGLFLLTLAIAQSKGRLSEADEARYLKEMRHLPVALQSVLALEPQIIGWAEDFA
RKDNALFLGRGLHYPIALEGALKLKEVTYIHAEAYAAGELKHGPLALVTSEMPVVAVAPN
DTLLEKLKSNLQEVRARGGVLYVLADGDTRIKGSEGLHVIRMPEHYGALSPLLHVVPLQL
LAYHTACARGTDVDKPRNLAKSVTVE