Protein Info for ABI39_RS20130 in Phocaeicola dorei CL03T12C01

Annotation: glutamate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01788: glutamate decarboxylase
  • amino acids 17 to 447 (431 residues), 554.6 bits, E=7e-171
• PF00282: Pyridoxal_deC
  • amino acids 56 to 367 (312 residues), 214.3 bits, E=1.1e-67

Best Hits

Swiss-Prot: 46% identical to DCE_LACLM: Glutamate decarboxylase (gadB) from Lactococcus lactis subsp. cremoris (strain MG1363)

KEGG orthology group: K01580, glutamate decarboxylase [EC: 4.1.1.15] (inferred from 98% identity to bvu:BVU_3895)

Predicted SEED Role

"Glutamate decarboxylase (EC 4.1.1.15)" in subsystem Acid resistance mechanisms (EC 4.1.1.15)

MetaCyc Pathways

• L-glutamate degradation IX (via 4-aminobutanoate) (1/1 steps found)
• GABA shunt I (1/4 steps found)
• GABA shunt II (1/4 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Butanoate metabolism
• Glutamate metabolism
• Taurine and hypotaurine metabolism
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.15

Protein Sequence (482 amino acids)

>ABI39_RS20130 glutamate decarboxylase (Phocaeicola dorei CL03T12C01)
MKDCNCDLRDGDAKTAVFGSNEMLQPAPVDTIPMEPTTPQIAYQMVKDETFAQTQPRLNL
ATFVTTYMDDYATKLMNEAININYIDETEYPRIAVMNAKCINIMANLWNSPEQAKWKSGA
LAIGSSEACMLGGVAAWLRWRDRRKAQGKPTDKPNFVISSGFQVVWEKFAQLWQIEMRQV
PLTLDKTILDPEEALKMCDENTICIVPIQGVTWTGLNDDVEALDKALDAYNAKTGYDIPI
HVDAATGGFILPFLSPETKWDFRLKWVLSISTSGHKFGLVYPGLGWVVWKDKKYLPDAMS
FSVNYLGANITQVGLNFSRPAAQILGQYYQFIRLGFQGYKAIQYNSMEITKYIHSEIAKM
APFVNYSDKVVNPLFIWYMKPEYAKNAKWTLYDLQAKLQQSGWMVPAYTLPENIQNYVVM
RVVVRQGFSRDMADMLLNDIKNAISEFEKLEYPTPTRIAQDKNIAVKGTVFTHNAHSNAA
KK