Protein Info for ABI39_RS19005 in Phocaeicola dorei CL03T12C01

Annotation: UvrD-helicase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 871 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details PF00580: UvrD-helicase" amino acids 158 to 262 (105 residues), 68.2 bits, see alignment E=1.9e-22 amino acids 462 to 614 (153 residues), 67.4 bits, see alignment E=3.5e-22 PF13245: AAA_19" amino acids 166 to 600 (435 residues), 75.1 bits, see alignment E=1.3e-24 PF13361: UvrD_C" amino acids 723 to 795 (73 residues), 57.1 bits, see alignment E=4.4e-19

Best Hits

KEGG orthology group: K03658, DNA helicase IV [EC: 3.6.4.12] (inferred from 100% identity to bsa:Bacsa_1157)

Predicted SEED Role

"DNA helicase IV" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (871 amino acids)

>ABI39_RS19005 UvrD-helicase domain-containing protein (Phocaeicola dorei CL03T12C01)
MQPLFIWVICIIAISVIVIAMVRTRLKNKSKELAEKLNHISAYSEKSNYEQAKERLSALK
EGAFIDIPSDLNNGFYGRVISATQEKDFINHYKVHFQEAYSLLKKLKAFNITPSETISKF
INDFGRINKLVKQHNDGVITFLLDTHRDFFDHCLKYPLDKQQRRSIVSEEDNCLVVSSAG
SGKTSSIVGKVKYLTEIKGIAPERILLISYTNKAAAELTERMATNGLKGYTFHKLAIDII
GKTTGTKPSICDNTDSLFVDIYHKLLDKSSFKKSIVEYFIDYQTNEADWEQRKNERREQL
SGLKNVQLKAMFPDMDGRAIYVRSEQEQKICFALSSLGVKFRYEEPYEHQLADEMHSQYR
PDFSIYFKQGGVTKRIYLEHFGVDEHGLVPAWFAKDKGITYEEANQKYNDGITWKKTAHE
KFGTQLLVTSSADFHYSDIRDKLRKLLAEAGVPIQEKTDEELYDLVLPKGSKQEKAFIRL
VVTFVTLVKSSCKSVKEVLKQAKNADDERSVFIIKNIFQPVYERYINALSDSNQIDFTDA
ILQATEICRTSHPVEYDYIIVDEFQDISVDRYNFLKVLREGNPPAKLYCVGDDWQSIYRF
SGSDMALFNQFPEYFGATEINKIETTYRFGEPLVSLSSNFIQRNKAQIQKNIHSFSSEMR
TELEFYAYDRRDYCNTIGQLVASIPSDKSIFLLGRYSFDDYYLSFMYQSIKEGNRFYYVI
GGRKIEFLTVHKSKGLEANYVILLQCNKDTYGFPSQVSDDPVLNYVLTKSDQFPYGEERR
LFYVAITRAKIKTLVLYDKRFPSVFVDEFLHPEKVSEESYVKHPNANKRWTRSADQFLLK
LHNEGKSVKYIANKMGRSQTSIVMRLNKLKK