Protein Info for ABI39_RS18245 in Phocaeicola dorei CL03T12C01

Annotation: insulinase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 939 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00675: Peptidase_M16" amino acids 56 to 177 (122 residues), 82.6 bits, see alignment E=2.9e-27 PF05193: Peptidase_M16_C" amino acids 209 to 393 (185 residues), 60.9 bits, see alignment E=1.6e-20 amino acids 691 to 869 (179 residues), 71.3 bits, see alignment E=9.9e-24

Best Hits

KEGG orthology group: K07263, zinc protease [EC: 3.4.24.-] (inferred from 97% identity to bvu:BVU_3629)

Predicted SEED Role

"Probable zinc protease pqqL (EC 3.4.99.-)" (EC 3.4.99.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-, 3.4.99.-

Use Curated BLAST to search for 3.4.24.- or 3.4.99.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (939 amino acids)

>ABI39_RS18245 insulinase family protein (Phocaeicola dorei CL03T12C01)
MTHFLRKMAAAWIILGSVSVGFAQQQTPPIPTDPNVRIGKLDNGLTYYIRHNELPEKRAD
FYIAQKVGSILEEDNQRGLAHFLEHMCFNGTKNFPDKTLIQYLESIGVKFGENLNAYTSI
DETVYNISNVPVIRDGVVDSCLLILHDWADDLTLDPKEIDSERGVIHEEWRTSTNAMMRM
YEKALPTLYPGSKYAYRLPIGIMEVVDNFPYQALRDYYEKWYRPDQQGIVVVGDIDVDKI
EAKIKKIFSPIKMPETPAEREYFQVPDNKETIVAIETDKEQANPVAYLCYKHEAIPNEQK
GNMDYLVVNYMKSMIENMLNARLNELTQTANPPFIFAQVSDQEFLISKTKDAFTGIVASK
EDGIDSAITAIVREIERAHKFGFTASEYARAKADYLRMLESAYNERNKVKNGAYVDEYVR
HFIDNEPIPGIENEYAIMNQIVPNLSVEMVNSLIPALVTDSNLVVNVFFPEKEGLKVPSK
KEVLAAINKVKAETLTAYEDKVSDEPLIPEKPQGGKITKQENGPFGSTILTLSNGVRVIL
KQTDFKADEIRMRAFSPGGSSLFPNDEIININVMNDVASIGGLGNFSNVDLEKVLAGKKA
SVSASVGGNTEGLSGSCSPKDFETLMQLVYLSFTAPRMDNDAFTSFKNRLQASLANQEAN
PMTALQDTLQKALYMGHPRTIRMKADMVDKIDYARIMEMYKDRFKDASDFTFIFVGNIKP
EETEPLIATYLGALPSVNRKETFRDNHIDMRQGDYKNIFNKKLETPKATVLVINNGQCAY
TLKNQIMMSMLSQILNIMYTESVREKEGGTYGVSAFGSLTKYPKEKAVLQIYFDTDPAKR
AKMTDIILNELNQFANEGPSTENLNKVKEFMLKKYKENAKENSYWVNMLDEYFWEGTDMN
TGYADIVNSITAKDLQEFTKALLEQNNRIEVSMTSEETK