Protein Info for ABI39_RS13980 in Phocaeicola dorei CL03T12C01

Annotation: Do family serine endopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details TIGR02037: peptidase Do" amino acids 64 to 481 (418 residues), 424.6 bits, see alignment E=2.2e-131 PF00089: Trypsin" amino acids 124 to 287 (164 residues), 76 bits, see alignment E=1.4e-24 PF13365: Trypsin_2" amino acids 125 to 260 (136 residues), 128.3 bits, see alignment E=1.4e-40 PF00595: PDZ" amino acids 312 to 385 (74 residues), 35.6 bits, see alignment E=3.4e-12 PF13180: PDZ_2" amino acids 326 to 397 (72 residues), 52.6 bits, see alignment E=1.6e-17 PF17820: PDZ_6" amino acids 334 to 386 (53 residues), 27.4 bits, see alignment 8.4e-10 PF12812: PDZ_1" amino acids 413 to 478 (66 residues), 31.1 bits, see alignment E=6.8e-11

Best Hits

KEGG orthology group: K01362, [EC: 3.4.21.-] (inferred from 98% identity to bvu:BVU_2737)

Predicted SEED Role

"Outer membrane stress sensor protease DegS" in subsystem Proteolysis in bacteria, ATP-dependent

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (507 amino acids)

>ABI39_RS13980 Do family serine endopeptidase (Phocaeicola dorei CL03T12C01)
MKQATKMVLGAAAIVAVSAGVAGVTTYSMLKPEPNKSVAFNDVFQQNPNTRLAALDATQM
QPVDLTQAAENSVHAVVHIKSTQESKTQTVTVRDPFYDFFGDIFGNGRGGGQQRQVQTPE
RVGFGSGVIISKDGYIVTNNHVIDNADVISVKLNDGREYKGRVIGTDPSTDLALVKIEAD
ELPTIPVGDSEALKVGEWVLAVGNPFNMTSTVTAGIVSAKARSLGVYNQGVESFIQTDAA
INQGNSGGALVNAKGELVGINSVLYSPTGAYSGYGFAIPTSIMKKVIADLKEYGTVQRAV
LGIKGTPINDDQQMMPEEIKKKVKELGATDGVLIAEVIDGGSAAGNLEVDDVIIGIDGKR
VKNFAELQEGLAKHRPGDKVTVKVLRDKKEKDIEMTLKNAQGTTKVVKSAGMDILGAAFR
EVPQELKRQLNLGYGVEVTGVTDGKMKAAGIRKGFIILKANGQPVKSVNDLEDVLKAATQ
SPDQVLFLSGMFPSGKRANYAVDLIQE