Protein Info for ABI39_RS11460 in Phocaeicola dorei CL03T12C01

Annotation: sodium-translocating pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 734 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 83 to 103 (21 residues), see Phobius details amino acids 132 to 153 (22 residues), see Phobius details amino acids 166 to 189 (24 residues), see Phobius details amino acids 247 to 264 (18 residues), see Phobius details amino acids 276 to 297 (22 residues), see Phobius details amino acids 309 to 333 (25 residues), see Phobius details amino acids 339 to 360 (22 residues), see Phobius details amino acids 384 to 414 (31 residues), see Phobius details amino acids 425 to 446 (22 residues), see Phobius details amino acids 490 to 508 (19 residues), see Phobius details amino acids 555 to 578 (24 residues), see Phobius details amino acids 621 to 639 (19 residues), see Phobius details amino acids 645 to 665 (21 residues), see Phobius details amino acids 712 to 733 (22 residues), see Phobius details TIGR01104: V-type H(+)-translocating pyrophosphatase" amino acids 8 to 727 (720 residues), 780.1 bits, see alignment E=1.2e-238 PF03030: H_PPase" amino acids 14 to 724 (711 residues), 894.1 bits, see alignment E=3.3e-273

Best Hits

Swiss-Prot: 87% identical to HPPA_BACTN: Putative K(+)-stimulated pyrophosphate-energized sodium pump (hppA) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 98% identity to bvu:BVU_2279)

Predicted SEED Role

"Pyrophosphate-energized proton pump (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (734 amino acids)

>ABI39_RS11460 sodium-translocating pyrophosphatase (Phocaeicola dorei CL03T12C01)
METYLFWIVPIASLLALALAWYFYKQMMLESEGTPTMEKIASYVRQGAMSYLKQQYKVVG
LVFLGLVILFSIMAYGFNLQNPWVPIAFLTGGFFSGLSGFLGMKTATYASARTANAAQHS
LNKGLRVAFRSGAVMGLVVVGLGLLDISFWYILLDYCIPPDTLNPSAKLCVITTTMLTFG
MGASTQALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDVAGM
GADLYESYCGSILATAALGAAAFIGSDDTVMQFKAVIAPMLIAAVGILLSIIGIFAVRTK
EDAGMKELLGSLATGTNLSSVLIVVATFLILWALGLENWVNISFAVVVGLIVGIVIGRST
EYYTSQSYKPTQRLAESGKTGPATVIISGIGLGMVSTTIPVLAVVVGIILSYWLASGFDF
ANISMGLYGIGIAAVGMLSTLGITLATDAYGPIADNAGGNAEMSGLGKEIRRRTDALDSL
GNTTAATGKGFAIGSAALTGLALLASYVEEIRIGLTRLGQTILELPNGITVDVHNASFTD
YMLYYDVTLMNPKVLSGMFLGSMMAFLFCGLTMNAVGRAAAHMVEEVRRQFREIKGILTG
EAEPDYARCVQISTKGAQREMVFPSLLAIIAPVATGLVFGVPGVIGLLIGGLSSGFVLAI
FMANAGGAWDNAKKYVEEGNFGGKGSEVHKATVTGDTVGDPFKDTSGPSLNILIKLMSMV
AIVMAGLTVAWSLF