Protein Info for ABI39_RS10330 in Phocaeicola dorei CL03T12C01

Annotation: M13 family metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 678 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF05649: Peptidase_M13_N" amino acids 45 to 422 (378 residues), 432.6 bits, see alignment E=1.8e-133 PF01431: Peptidase_M13" amino acids 474 to 675 (202 residues), 244.6 bits, see alignment E=7.7e-77

Best Hits

KEGG orthology group: K07386, putative endopeptidase [EC: 3.4.24.-] (inferred from 99% identity to bvu:BVU_2033)

Predicted SEED Role

"Endothelin-converting enzyme 1 precursor (EC 3.4.24.71)" (EC 3.4.24.71)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.- or 3.4.24.71

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (678 amino acids)

>ABI39_RS10330 M13 family metallopeptidase (Phocaeicola dorei CL03T12C01)
MKAKHYLPMAVLALAVAAGCDSKKEAVMTSGIDLTNLDTTAVQGADFYQYACGGWMKKHP
LTNEYSRFGSFDMLAENNREQLKGLIVEIAAGQNAQGTIGQKIGDIYNLAMDSVKLNADG
VTPIQADLEKIASVKDKSEIVPLMAELAHSGVFPYFSFYVGADIMDSKSNLFQLYQGGIS
LGEREYYLDNDDVTTNIRNKYKEHIVKMFQLAGFDEAAAKKKMEAVMDIETRIAKASFSA
VEQRNPAANYHKMSLDELKKEIPGIDWDAFLNGIGVKGVTELSVSQVEPIKEVEKIINSL
PVENQIAYMQWNLIDRAAGYLSDDLVAQNFDFYGKTLSGKQANQPRWKRAVSTVNGVLGE
AVGQMYVEKYFPAAAKERMVQLVKNLQTALGERIRNLEWMGDSTKIKAIEKLNSFYVKVG
YPDKWRDYTGLNIEKDSYWANVKRATEFELDYMLSKAGKPVDRDEWGMTPQTVNAYYNPT
TNEICFPAGILQYPFFDMNADDAFNYGAIGVVIGHEMTHGFDDQGRQFDKDGNLKDWWTA
EDAKRFEERAQVMVNFFDSIQVLPELNANGSLTLGENIADHGGLQVSFQAFKNATKDAPL
PVEDGFTPEQRFFLSYAGVWAGNIRDEQIRLQTKSDPHSLGRWRVNGALPQIGAWYDAFG
IKEGDPMYLAPEKRVSIW