Protein Info for ABI39_RS01810 in Phocaeicola dorei CL03T12C01

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 665 PF17391: Urocanase_N" amino acids 79 to 204 (126 residues), 174.2 bits, see alignment E=1.4e-55 TIGR01228: urocanate hydratase" amino acids 91 to 631 (541 residues), 428.9 bits, see alignment E=1.6e-132 PF01175: Urocanase" amino acids 207 to 430 (224 residues), 265.3 bits, see alignment E=5.7e-83 PF17392: Urocanase_C" amino acids 435 to 631 (197 residues), 270.3 bits, see alignment E=1.3e-84

Best Hits

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 98% identity to bvu:BVU_0333)

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (665 amino acids)

>ABI39_RS01810 urocanate hydratase (Phocaeicola dorei CL03T12C01)
MTITLSNDLPAYPTFTEGIRRAPDRGYRLTPAQTETALRNALRYIPVELHEQLAPELTDE
LLTRGKIYGYRFRPEGDLKAKPIDEYKGNCIEGKAFQVMIDNNLSFDIALYPYELVTYGE
TGQVCQNWMQYRLIKQYLEIMTNEQTLVVESGHPLGLFQSHPEAPRVIITNSMMVGMFDN
QKDWEIAAQMGVANYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRMKLGVPQNGNLNGHLF
VSSGLGGMSGAQPKAAEIAGAVAIIAEVDYSRIETRHRQGWVQHITSDLSEAYRLATDAM
ARRIPCSIAYHGNVVNLLEYALHHNIHIELLSDQTSCHAVYEGGYCPAGISFEERTRMLK
EDRETFDKMVDETLRRHFHVIKELVARGTYFFDYGNSFMKAIYDAGVKEISRNGTDEKDG
FIWPSYVEDIMGPQLFDYGYGPFRWVCLSGKKEDLIKTDHAAMECIPKDRRGQDMDNWIW
IRDAEKNNLVVGTQARILYQDALGRMNIALRFNEMVRRGEVGPIMLGRDHHDVSGTDSPF
RETSNIKDGSNVMADMAVQCFAGNCARGMNLVALHNGGGVGIGKAINGGFGMVCDGSERV
DRILRSSMLWDVMGGVARRSWARNPHAMETSAEFNESHADGYHITLPHLAEDSLINKILK
DKGIK