Protein Info for A4249_RS14985 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: DHA2 family efflux MFS transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 511 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 45 to 66 (22 residues), see Phobius details amino acids 75 to 94 (20 residues), see Phobius details amino acids 100 to 124 (25 residues), see Phobius details amino acids 132 to 151 (20 residues), see Phobius details amino acids 163 to 183 (21 residues), see Phobius details amino acids 196 to 215 (20 residues), see Phobius details amino acids 227 to 245 (19 residues), see Phobius details amino acids 265 to 289 (25 residues), see Phobius details amino acids 301 to 319 (19 residues), see Phobius details amino acids 327 to 344 (18 residues), see Phobius details amino acids 356 to 375 (20 residues), see Phobius details amino acids 474 to 496 (23 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 10 to 487 (478 residues), 413.2 bits, see alignment E=7.6e-128 PF07690: MFS_1" amino acids 14 to 407 (394 residues), 165.4 bits, see alignment E=8.8e-53

Best Hits

KEGG orthology group: None (inferred from 76% identity to bsb:Bresu_0417)

Predicted SEED Role

"Multidrug resistance protein B"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168NSR9 at UniProt or InterPro

Protein Sequence (511 amino acids)

>A4249_RS14985 DHA2 family efflux MFS transporter permease subunit (Brevundimonas sp. GW460-12-10-14-LB2)
MNWTMLLLGFAGMVVGQFMAILDIQIVAASLPQIQAGVGASADEISWIQTAYLIPEVVMI
PLSGFLSRLWGTQRLFLVSCAGFVLMSIATGLSSSIDMMILFRAIQGFVGGAMIPTVFAV
AFTAFPPDKRVTASVVMGLIVTLAPTVGPTLGGHLTEWLSWRWLFFINVGPGLLVLFLVG
RYGNFDKGDPSLAKGFDWWGLGLMAAFLMSMQFVLEEGAKNDWFDDTHILLLTVVAAVAG
PIFIWRSLTYRQPIVELRAFGNRNFLVGFIMTFIVGFALFGGTFLLPLFLGRVLGYSSSE
VGTTMVVSGLAMFATGPFAGRLVRKLDARVLMFGGFMLCAWGMWEARVVTDDWGFWNFAS
VQAFRGVGVMLAMIASQQVTMATLPPHMVKNASGLVNLSRNVGGAFGLAILNTSLTSNTA
LHMSELTSAIGQGDQAMRNMMAGMAQRFAGSIDPAASAMKAIYGMLQKQATTMAFGDAFA
LLAILCAGAAFVTLAAQPVKAQAGAPPSDVH