Protein Info for A4249_RS14585 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: glucose-6-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00342: PGI
  • amino acids 46 to 534 (489 residues), 587.7 bits, E=9e-181

Best Hits

Swiss-Prot: 59% identical to G6PI_CAUSK: Glucose-6-phosphate isomerase (pgi) from Caulobacter sp. (strain K31)

KEGG orthology group: K01810, glucose-6-phosphate isomerase [EC: 5.3.1.9] (inferred from 82% identity to bsb:Bresu_0193)

Predicted SEED Role

"Glucose-6-phosphate isomerase (EC 5.3.1.9)" in subsystem Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 5.3.1.9)

MetaCyc Pathways

• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (22/26 steps found)
• glycolysis III (from glucose) (10/11 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (14/17 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• gluconeogenesis III (10/12 steps found)
• homolactic fermentation (10/12 steps found)
• Bifidobacterium shunt (12/15 steps found)
• colanic acid building blocks biosynthesis (9/11 steps found)
• gluconeogenesis I (10/13 steps found)
• glycolysis I (from glucose 6-phosphate) (10/13 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• GDP-mannose biosynthesis (3/4 steps found)
• sucrose degradation III (sucrose invertase) (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• O-antigen building blocks biosynthesis (E. coli) (8/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• heterolactic fermentation (12/18 steps found)
• D-sorbitol biosynthesis I (1/3 steps found)
• sucrose biosynthesis III (1/3 steps found)
• glycolysis V (Pyrococcus) (6/10 steps found)
• formaldehyde oxidation I (3/6 steps found)
• chitin biosynthesis (5/9 steps found)
• 1,5-anhydrofructose degradation (2/5 steps found)
• sucrose biosynthesis II (4/8 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (3/7 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (8/14 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• 1,3-propanediol biosynthesis (engineered) (4/9 steps found)
• starch biosynthesis (2/10 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (7/18 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (5/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (10/33 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (19/56 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Glycolysis / Gluconeogenesis
• Pentose phosphate pathway
• Starch and sucrose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.9

Sequence Analysis Tools

See A0A160I2Q7 at UniProt or InterPro

Protein Sequence (539 amino acids)

>A4249_RS14585 glucose-6-phosphate isomerase (Brevundimonas sp. GW460-12-10-14-LB2)
MTRDAAWTAFDQAAAEAASARIVDQFAADPDRLARMSVEAAGLYLDLSKQSWTKAAFDAC
LDLARASDVEGRRAALFAGEAVNLTEGRAVLHPALRAAPGADFKALGEPVSAEVDAVRAD
MKAYADAVRSGAEAGATGKTFEAIVHVGIGGSDLGPRVVWDALRPLDPAIDLRFVASIDP
RDMAEALTGLNPETTLVVVVSKTFTTQETLANAEAAKAWLAASLPAEGMTKHFIGVTAAP
EKAAAFGCGRTFAFRDWVGGRYSLWSAVSLSCGIALGWDVFEQMLAGAAAMDEHFVSAPL
ERNAPVLLALAQVFNVDGLNRPARTVAPYAHALRRLPSFLQQLEMESNGKRVHRDGTPVT
RQTCPVVFGEPGTNGQHAFFQQIHQGPQTVPAEFVIVAKTHADAPESPPEAPLWSNALAQ
GQALMLGKTTEAAKAEGLAQGLSEEEATRLASHRTFTGNRPSTAILMDRLTPETLGALLA
LYEHKTFVEGVIWDINSFDQWGVELGKVLAKAILKDVDAGGPSADLDPSTAALMTRLMG