Protein Info for A4249_RS13595 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: murein biosynthesis integral membrane protein MurJ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 531 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 53 to 70 (18 residues), see Phobius details amino acids 89 to 110 (22 residues), see Phobius details amino acids 126 to 150 (25 residues), see Phobius details amino acids 158 to 180 (23 residues), see Phobius details amino acids 188 to 211 (24 residues), see Phobius details amino acids 232 to 252 (21 residues), see Phobius details amino acids 273 to 293 (21 residues), see Phobius details amino acids 314 to 335 (22 residues), see Phobius details amino acids 355 to 377 (23 residues), see Phobius details amino acids 386 to 407 (22 residues), see Phobius details amino acids 414 to 437 (24 residues), see Phobius details amino acids 453 to 474 (22 residues), see Phobius details amino acids 486 to 509 (24 residues), see Phobius details TIGR01695: murein biosynthesis integral membrane protein MurJ" amino acids 2 to 506 (505 residues), 326.9 bits, see alignment E=1.1e-101 PF03023: MurJ" amino acids 29 to 479 (451 residues), 277.4 bits, see alignment E=3e-86 PF01554: MatE" amino acids 278 to 399 (122 residues), 26.9 bits, see alignment E=5.5e-10 PF14667: Polysacc_synt_C" amino acids 355 to 507 (153 residues), 45.7 bits, see alignment E=1.1e-15

Best Hits

KEGG orthology group: K03980, virulence factor (inferred from 79% identity to bsb:Bresu_0291)

Predicted SEED Role

"Proposed peptidoglycan lipid II flippase MurJ" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168NQE1 at UniProt or InterPro

Protein Sequence (531 amino acids)

>A4249_RS13595 murein biosynthesis integral membrane protein MurJ (Brevundimonas sp. GW460-12-10-14-LB2)
MSLARNTLVQSTLTLGSRILGFVRDMALAARFGQGPMMDAFTTALMLPNMFRRLFAEGAF
AQAFVPVYGGVRAREGEEAAAVTASEALSFMLAVVAGFCILLQVVMPWIMPWLLSAYQGQ
PEVLRAAVIATQLAMPYLACMTVASLLSGVLNTGGRFALSAAVPVFLNLCTLAALMPPVI
LPIPQETVLLMVTAAVTVSGLIQAGLLWWGVRRLGVRLKIGLPRITPNVRHTLALAVPGA
LAGGALQINSLVSQFLTGSDEGARSVLYNADRLYQLPLGLVGVAIGLALVPRLTKAFVDG
DHEGGQKTLDDGINLAMAFTLPAAVALFVIPFFIIDATVTRGAFTSADAARTADVLRQFA
WGVPAFVLAKVLTPPFFARQDTRRPMIFAVASVVITVILGSALFFWFRRQGWDGVLGLAI
ATSTSAWVNVALLGGVLIRENSWRPSPAFLSRIARVIAASAMMAALLFAADVFYPQLSRL
FLAKEIAVLVVCGAGAGLYGFCLLAFRAVTISELKATLKREPGGGAVSGLD