Protein Info for A4249_RS12990 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 272 transmembrane" amino acids 15 to 32 (18 residues), see Phobius details amino acids 44 to 65 (22 residues), see Phobius details amino acids 81 to 104 (24 residues), see Phobius details amino acids 125 to 146 (22 residues), see Phobius details amino acids 155 to 178 (24 residues), see Phobius details amino acids 188 to 209 (22 residues), see Phobius details amino acids 245 to 264 (20 residues), see Phobius details PF01061: ABC2_membrane" amino acids 27 to 234 (208 residues), 32.5 bits, see alignment E=3.2e-12

Best Hits

Swiss-Prot: 38% identical to CTRC_NEIMB: Capsule polysaccharide export inner-membrane protein CtrC (ctrC) from Neisseria meningitidis serogroup B (strain MC58)

KEGG orthology group: K09688, capsular polysaccharide transport system permease protein (inferred from 59% identity to bsb:Bresu_3274)

Predicted SEED Role

"Capsular polysaccharide ABC transporter, permease protein KpsM" in subsystem Capsular Polysaccharide (CPS) of Campylobacter or Rhamnose containing glycans

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I1C2 at UniProt or InterPro

Protein Sequence (272 amino acids)

>A4249_RS12990 ABC transporter permease (Brevundimonas sp. GW460-12-10-14-LB2)
MSELTVAHPKRRRRGVLGFLSEQFRIIGALFLREMATRFGREGIGFVWLIVEPLAFCVGV
LIMWSLTKPAYEHGVKLQAFVMTGYISLIVLRHMVAYSLGALQANIGLLHHRKVKPMHVF
LTRNLLEFGGATCAFIVVYVALIMIGQVDPPHDLLIIYLGWLLLAWIGMGFALTLAGLSI
RFEMLERIVPLLTYLLIPLSGAFFMVDWLPPRIQEPFLLMPFAHPIEMIRAGVFSEFVKT
HYNPPYALAVGTGMNIFGMLLIAGSRDRIDVE