Protein Info for A4249_RS11755 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: efflux RND transporter periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF16576: HlyD_D23" amino acids 93 to 274 (182 residues), 52.1 bits, see alignment E=1.1e-17 TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 95 to 390 (296 residues), 117.1 bits, see alignment E=4e-38 PF13437: HlyD_3" amino acids 215 to 303 (89 residues), 41.9 bits, see alignment E=2.9e-14

Best Hits

KEGG orthology group: None (inferred from 80% identity to bsb:Bresu_1651)

Predicted SEED Role

"Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A161IWY0 at UniProt or InterPro

Protein Sequence (400 amino acids)

>A4249_RS11755 efflux RND transporter periplasmic adaptor subunit (Brevundimonas sp. GW460-12-10-14-LB2)
MRKRTSNKTLLIGGVAALVILGGGGLWLATRSSEPAAPAAAEGEAGHAEEEGGHAEGEAA
GAETEGRIELTTAEIQAAGITVVGVGGGGGGETRLAGRVEPMVDSRAAVGAAVGGRVERV
LVAPGQSVRAGQPLVSLVSGEAATFRADADAAGASAEAARQAYERNRSLADQGIVARQEV
EASRAQFLSAEAATRAARARSAAAGSPNASGRLSVTSPISGVVSSVQVGPGGFVAQGGVV
AEVSNPARVEMVFNAPPALAANVRAGAPMRVTGPNGEFDAVVTGVAADAGLSESGATVIR
ARPSGASLPPAGSAVTGAIVTGEATGGMTVPTEAVQTVDGNTVVFVQVEGGFQAVQVLAG
RQAAGRTEILRGLTGSERVASANAFLLKAEMAKGEAEHGH