Protein Info for A4249_RS11645 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: helix-turn-helix domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 135 PF13411: MerR_1" amino acids 11 to 74 (64 residues), 59.5 bits, see alignment E=4.2e-20 PF00376: MerR" amino acids 11 to 45 (35 residues), 56 bits, see alignment E=4.1e-19 PF09278: MerR-DNA-bind" amino acids 51 to 112 (62 residues), 66.5 bits, see alignment E=4.1e-22

Best Hits

Swiss-Prot: 41% identical to MERR_BACCE: Mercuric resistance operon regulatory protein (merR1) from Bacillus cereus

KEGG orthology group: None (inferred from 61% identity to xau:Xaut_2900)

Predicted SEED Role

"Heavy metal resistance transcriptional regulator HmrR" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I0T2 at UniProt or InterPro

Protein Sequence (135 amino acids)

>A4249_RS11645 helix-turn-helix domain-containing protein (Brevundimonas sp. GW460-12-10-14-LB2)
MVLQTGLLRAQLAKLTGCNLETIRYYEKVGLLPPPPRSANGYRVYSPDLTQRLRFILRAR
DIGFSMEETRSLLALTDTGTQTCAEVKHKTEVQLEDVRAKIADLRRMERILANAAAKCSG
GEVPECPVLEALTSD