Protein Info for A4249_RS08555 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 525 signal peptide" amino acids 1 to 16 (16 residues), see Phobius details PF00563: EAL" amino acids 274 to 500 (227 residues), 201.9 bits, see alignment E=5.2e-64

Best Hits

KEGG orthology group: None (inferred from 56% identity to bsb:Bresu_2608)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HXM4 at UniProt or InterPro

Protein Sequence (525 amino acids)

>A4249_RS08555 EAL domain-containing protein (Brevundimonas sp. GW460-12-10-14-LB2)
MTLTTRLLGLAFASADTLVEVDPKGVVAFAIGAGAVAGEDAGATWTGRPLLDLLHDGAST
LTALQGMKAGVRIPATSILVAAGPDRVRRASFRAFVLPQMAPAVSCAISYEGPAFALEDL
ETRPLLEPEDFLADAGRVLESNPDLALSFLDITGLENVTGEAADRLNRRIEATLQSAAVE
GSSASQVTGVRFALLRPANDRRDIAAEIVEAGRAEGLSLGAEAFSSPVPPGSDSLCVLRA
MRFAIEGCLKGDGLANPQIAFADSLKRTFRDAETFRSLVKSREFQVHYQPIVHLDSRAVH
HFEALTRFSGNNGPAEAIRMAEELDMIESFDLAVAEKVLKRMRQPGAGLLKMAINVSGAS
LGDDTYVEQLLRMTAGAPEERRRLMVEVTETSAVADIEAADRRLAALREAGIKVCIDDFG
AGAAAFDYLRKLSVDSVKIDGAIVRDIQTDQRSKAMLHSIVELCRSMRLETIAEMIETDG
VASELKAAGVEYGQGWLFGRAEAEPRTQLSSPSMVRRKGAVEAWG