Protein Info for A4249_RS08030 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: NADH:ubiquinone oxidoreductase subunit NDUFA12

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 130 PF05071: NDUFA12" amino acids 24 to 129 (106 residues), 94.8 bits, see alignment E=2.4e-31

Best Hits

KEGG orthology group: K00356, NADH dehydrogenase [EC: 1.6.99.3] (inferred from 81% identity to bsb:Bresu_2206)

Predicted SEED Role

"NADH:ubiquinone oxidoreductase 17.2 kD subunit" in subsystem Respiratory Complex I

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.6.99.3

Use Curated BLAST to search for 1.6.99.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160HYS1 at UniProt or InterPro

Protein Sequence (130 amino acids)

>A4249_RS08030 NADH:ubiquinone oxidoreductase subunit NDUFA12 (Brevundimonas sp. GW460-12-10-14-LB2)
MLSKIFGWWEGATIGTRFTIAKRGRFVGQDENGNRYYESRDNVSYDGRKRRWVIYDGYAE
ASKVTPDWHGWLHYTFDLPPTEQPLPRRAWEKEHLPNLTGTPLAWRPPGSLAGDAKRPAA
TGDYQAWTPE