Protein Info for A4249_RS07630 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: carboxylesterase/lipase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00135: COesterase
  • amino acids 2 to 468 (467 residues), 287.3 bits, E=4.4e-89
• PF20434: BD-FAE
  • amino acids 69 to 249 (181 residues), 38.7 bits, E=1.2e-13
• PF07859: Abhydrolase_3
  • amino acids 83 to 190 (108 residues), 29.2 bits, E=1.2e-10

Best Hits

KEGG orthology group: K03927, carboxylesterase type B [EC: 3.1.1.1] (inferred from 71% identity to bsb:Bresu_3106)

Predicted SEED Role

"carboxylesterase type B"

MetaCyc Pathways

• methylsalicylate degradation (2/2 steps found)
• aspartame degradation (1/2 steps found)
• methyl indole-3-acetate interconversion (1/2 steps found)
• superpathway of methylsalicylate metabolism (1/5 steps found)
• retinol biosynthesis (1/7 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Drug metabolism - other enzymes

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.1

Use Curated BLAST to search for 3.1.1.1

Sequence Analysis Tools

See A0A160HZB5 at UniProt or InterPro

Protein Sequence (487 amino acids)

>A4249_RS07630 carboxylesterase/lipase family protein (Brevundimonas sp. GW460-12-10-14-LB2)
MTTAGPVIGLRREGISVFRGVRYGAPTRRFQPPEKPTPWRDPVRATRYGAASPQRGDEPN
QSEDCLFLNVRTPGTDAGRRPVMVYIHGGAYSSGSGSDPLYDGTRLAARGDVVVVTLNHR
LNVFGYAYLARLAPGFEDSGNVGQLDLILALQWIRDNIAAFGGDPSRVMLFGQSGGGAKI
ATLMATPAAQGLFHRAATMSGQQVTASGPINATTRATTWLNALGLTPDRAAEAATMPVER
LLEAQSAEDPILGFGGLYFGPVLDFRTLPRHPFYPDAAPLGRSIPMIIGNTREETLGFMG
NDPKNVGLTWETLKTRLSPGVMRIDITPEAVIAGYRAMHPEWSPDQVLIAATTAGRSWRG
AVIEAEERAKAGAPAWVYQLDFPGELASGRKGAFHTADIPLVFDNVEATGSRTRGPDAQI
MSDRMSDAFIALARDGDPNHAGLPRWDRYELPRRQTMLMDIQPRMVDDPRGDERAFFSAI
PYIQPGT