Protein Info for A4249_RS04765 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: ATP-dependent DNA helicase RecG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 695 PF17191: RecG_wedge" amino acids 17 to 171 (155 residues), 24.9 bits, see alignment E=3.5e-09 PF04851: ResIII" amino acids 262 to 424 (163 residues), 35 bits, see alignment E=3.4e-12 PF00270: DEAD" amino acids 264 to 430 (167 residues), 79.6 bits, see alignment E=5.7e-26 PF00271: Helicase_C" amino acids 474 to 579 (106 residues), 66.5 bits, see alignment E=6e-22 PF19833: RecG_dom3_C" amino acids 611 to 676 (66 residues), 32.9 bits, see alignment E=1.5e-11

Best Hits

KEGG orthology group: K03655, ATP-dependent DNA helicase RecG [EC: 3.6.4.12] (inferred from 81% identity to bsb:Bresu_1929)

Predicted SEED Role

"ATP-dependent DNA helicase RecG (EC 3.6.1.-)" in subsystem DNA-replication (EC 3.6.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-, 3.6.4.12

Use Curated BLAST to search for 3.6.1.- or 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A161I7G6 at UniProt or InterPro

Protein Sequence (695 amino acids)

>A4249_RS04765 ATP-dependent DNA helicase RecG (Brevundimonas sp. GW460-12-10-14-LB2)
MRPQILFPLFAEVSTLKGVGPRVLPLVQKVAGPLVRDLLFLSPSGVIVRRPAEAASAIDG
EVGVFTVTIDRLFTPSRPGAPLKVRASDPTGFVHLVWFGGSPQHIDRLLPRGETRLVSGK
VERFNGEVQIVHPDIVTLDKAADIPASEPVYPATQGLTSRQLRKLVQAALPAAPDLPEWQ
DPAWLKKQNWLGWRAALDALHAPTAETDLSPDAPARQRLAYDEFLAHQLALARRRRAREI
RPAPVIAPGAASEHLLQALPFQLTNAQAQAIAEIRRDLASGQQMGRLLQGDVGSGKTAVA
ALALADAAASSFQSTLMAPTEILARQHYEKLGPILDAAGVAAVLLTGRDTPAQRREKLAD
LASGHAQVAIGTHALFQDAVRFDRLALAVIDEQHRFGVNERQRLQAKGDPRLGAVHLLTM
SATPIPRTLELTQYGELEVSRLMEKPPGRTPVTTAVLPLARIGEVAARLKTAVESGAQAY
WICPLVEESEAIDLAAAVDRADDLRRLLGVEVGLAHGQMPGAEREAVMADFADGRLPVLV
ATTVVEVGVDVPNASIMVIEHADRFGLAQLHQLRGRVGRGSKASSCILLYGGQDGALGET
AKERLETLRRTEDGFEIAEEDFRLRGGGDPLGLKQSGFPAYRFADPIRHRSLMLAAADDA
RLIMNRDPDLTSERGQAVQVLEELFDWKNHKAGAS