Protein Info for b3903 in Escherichia coli BW25113

Name: rhaA
Annotation: L-rhamnose isomerase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to RHAA_ECODH: L-rhamnose isomerase (rhaA) from Escherichia coli (strain K12 / DH10B)

KEGG orthology group: K01813, L-rhamnose isomerase [EC: 5.3.1.14] (inferred from 100% identity to eco:b3903)

MetaCyc: 100% identical to L-rhamnose isomerase (Escherichia coli K-12 substr. MG1655)
L-rhamnose isomerase. [EC: 5.3.1.14]; 5.1.3.- [EC: 5.3.1.14]

Predicted SEED Role

"L-rhamnose isomerase (EC 5.3.1.14)" in subsystem L-rhamnose utilization (EC 5.3.1.14)

MetaCyc Pathways

superpathway of fucose and rhamnose degradation (12/12 steps found)
L-rhamnose degradation I (5/5 steps found)
L-lyxose degradation (4/4 steps found)
superpathway of pentose and pentitol degradation (18/42 steps found)

KEGG Metabolic Maps

Fructose and mannose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.14

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P32170 at UniProt or InterPro

Protein Sequence (419 amino acids)

>b3903 L-rhamnose isomerase (NCBI) (Escherichia coli BW25113)
MTTQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVSGFENPEGSLTGGIQ
ATGNYPGKARNASELRADLEQAMRLIPGPKRLNLHAIYLESDTPVSRDQIKPEHFKNWVE
WAKANQLGLDFNPSCFSHPLSADGFTLSHADDSIRQFWIDHCKASRRVSAYFGEQLGTPS
VMNIWIPDGMKDITVDRLAPRQRLLAALDEVISEKLNPAHHIDAVESKLFGIGAESYTVG
SNEFYMGYATSRQTALCLDAGHFHPTEVISDKISAAMLYVPQLLLHVSRPVRWDSDHVVL
LDDETQAIASEIVRHDLFDRVHIGLDFFDASINRIAAWVIGTRNMKKALLRALLEPTAEL
RKLEAAGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPAGSEWLESVRAYEKEILSRRG