Protein Info for b4461 in Escherichia coli BW25113

Name: yfjD
Annotation: predicted inner membrane protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 transmembrane" amino acids 7 to 25 (19 residues), see Phobius details amino acids 62 to 84 (23 residues), see Phobius details amino acids 92 to 112 (21 residues), see Phobius details amino acids 126 to 149 (24 residues), see Phobius details PF01595: CNNM" amino acids 11 to 184 (174 residues), 183.1 bits, see alignment E=6e-58 PF00571: CBS" amino acids 278 to 326 (49 residues), 27.9 bits, see alignment 3.7e-10 PF03471: CorC_HlyC" amino acids 344 to 418 (75 residues), 68.8 bits, see alignment E=4.8e-23

Best Hits

Swiss-Prot: 100% identical to YFJD_ECOLI: UPF0053 inner membrane protein YfjD (yfjD) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to eco:b4461)

Predicted SEED Role

"Hemolysins and related proteins containing CBS domains"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P37908 at UniProt or InterPro

Protein Sequence (428 amino acids)

>b4461 predicted inner membrane protein (RefSeq) (Escherichia coli BW25113)
MEHISTTTLIIILIIMVVISAYFSGSETGMMTLNRYRLRHMAKQGNRSAKRVEKLLRKPD
RLISLVLIGNNLVNILASALGTIVGMRLYGDAGVAIATGVLTFVVLVFAEVLPKTIAALY
PEKVAYPSSFLLAPLQILMMPLVWLLNAITRMLMRMMGIKTDIVVSGSLSKEELRTIVHE
SRSQISRRNQDMLLSVLDLEKMTVDDIMVPRSEIIGIDINDDWKSILRQLSHSPHGRIVL
YRDSLDDAISMLRVREAWRLMSEKKEFTKETMLRAADEIYFVPEGTPLSTQLVKFQRNKK
KVGLVVNEYGDIQGLVTVEDILEEIVGDFTTSMSPTLAEEVTPQNDGSVIIDGTANVREI
NKAFNWHLPEDDARTVNGVILEALEEIPVAGTRVRIGEYDIDILDVQDNMIKQVKVFPVK
PLRESVAE