Protein Info for b4388 in Escherichia coli BW25113

Name: serB
Annotation: 3-phosphoserine phosphatase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 322 PF18429: DUF5609" amino acids 36 to 99 (64 residues), 67.2 bits, see alignment E=1.9e-22 TIGR00338: phosphoserine phosphatase SerB" amino acids 97 to 315 (219 residues), 315.3 bits, see alignment E=2.1e-98 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 112 to 283 (172 residues), 89.8 bits, see alignment E=2e-29 PF00702: Hydrolase" amino acids 113 to 284 (172 residues), 72 bits, see alignment E=1.9e-23 PF12710: HAD" amino acids 114 to 280 (167 residues), 75.6 bits, see alignment E=1.5e-24 PF08282: Hydrolase_3" amino acids 242 to 312 (71 residues), 50.5 bits, see alignment E=4.9e-17

Best Hits

Swiss-Prot: 100% identical to SERB_ECO57: Phosphoserine phosphatase (serB) from Escherichia coli O157:H7

KEGG orthology group: K01079, phosphoserine phosphatase [EC: 3.1.3.3] (inferred from 100% identity to eco:b4388)

MetaCyc: 100% identical to phosphoserine phosphatase (Escherichia coli K-12 substr. MG1655)
Phosphoserine phosphatase. [EC: 3.1.3.3]

Predicted SEED Role

"Phosphoserine phosphatase (EC 3.1.3.3)" in subsystem Glycine and Serine Utilization or Serine Biosynthesis (EC 3.1.3.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.3.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0AGB0 at UniProt or InterPro

Protein Sequence (322 amino acids)

>b4388 3-phosphoserine phosphatase (NCBI) (Escherichia coli BW25113)
MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLG
AAMVIVAAWCVEDYQVIRLAGSLTARATRLAHEAQLDVAPLGKIPHLRTPGLLVMDMDST
AIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSRVATLKGADANILQQVRENL
PLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVI
GDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKAE
VTIRHADLMGVFCILSGSLNQK