Protein Info for b3261 in Escherichia coli BW25113

Name: fis
Annotation: DNA-binding protein Fis (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 98 PF02954: HTH_8" amino acids 55 to 95 (41 residues), 53.8 bits, see alignment E=6.2e-19

Best Hits

Swiss-Prot: 100% identical to FIS_SALA4: DNA-binding protein Fis (fis) from Salmonella agona (strain SL483)

KEGG orthology group: K03557, Fis family transcriptional regulator, factor for inversion stimulation protein (inferred from 100% identity to ecp:ECP_3354)

Predicted SEED Role

"DNA-binding protein Fis" in subsystem DNA structural proteins, bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0A6R3 at UniProt or InterPro

Protein Sequence (98 amino acids)

>b3261 DNA-binding protein Fis (NCBI) (Escherichia coli BW25113)
MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQ
PLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN