Protein Info for b3091 in Escherichia coli BW25113

Name: uxaA
Annotation: altronate hydrolase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08666: SAF
  • amino acids 10 to 80 (71 residues), 46.8 bits, E=5.2e-16
• PF04295: GD_AH_second
  • amino acids 111 to 244 (134 residues), 162.4 bits, E=9.8e-52
• PF20629: GD_AH_C
  • amino acids 255 to 494 (240 residues), 334.9 bits, E=3.8e-104

Best Hits

Swiss-Prot: 100% identical to UXAA_ECOLI: Altronate dehydratase (uxaA) from Escherichia coli (strain K12)

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 100% identity to eco:b3091)

MetaCyc: 100% identical to D-altronate dehydratase (Escherichia coli K-12 substr. MG1655)
Altronate dehydratase. [EC: 4.2.1.7]

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• superpathway of hexuronide and hexuronate degradation (10/10 steps found)
• D-galacturonate degradation I (5/5 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.7

Sequence Analysis Tools

See P42604 at UniProt or InterPro

Protein Sequence (495 amino acids)

>b3091 altronate hydrolase (NCBI) (Escherichia coli BW25113)
MQYIKIHALDNVAVALADLAEGTEVSVDNQTVTLRQDVARGHKFALTDIAKGANVIKYGL
PIGYALADIAAGVHVHAHNTRTNLSDLDQYRYQPDFQDLPAQAADREVQIYRRANGDVGV
RNELWILPTVGCVNGIARQIQNRFLKETNNAEGTDGVFLFSHTYGCSQLGDDHINTRTML
QNMVRHPNAGAVLVIGLGCENNQVAAFRETLGDIDPERVHFMICQQQDDEIEAGIEHLHQ
LYNVMRNDKREPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPE
MFGAEQLLMDHCRDEATFEKLVTMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEDKSL
GCTQKAGSSVVVDVLRYGERLKTPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTPY
GGFVPTVKIATNSELAAKKKHWIDFDAGQLIHGKAMPQLLEEFIDTIVEFANGKQTCNER
NDFRELAIFKSGVTL