Protein Info for b2520 in Escherichia coli BW25113

Name: yfhM
Annotation: hypothetical protein (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1653 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF17970: bMG1" amino acids 59 to 163 (105 residues), 161.9 bits, see alignment 2.3e-51 PF21142: A2M_bMG2" amino acids 169 to 287 (119 residues), 171.5 bits, see alignment 3.3e-54 PF11974: bMG3" amino acids 289 to 381 (93 residues), 80.4 bits, see alignment 4.9e-26 PF01835: MG2" amino acids 388 to 479 (92 residues), 74.3 bits, see alignment 4.5e-24 PF17972: bMG5" amino acids 485 to 610 (126 residues), 132 bits, see alignment 8.8e-42 PF17962: bMG6" amino acids 637 to 741 (105 residues), 89.3 bits, see alignment 1.1e-28 PF07703: A2M_BRD" amino acids 759 to 905 (147 residues), 60.8 bits, see alignment E=1e-19 PF00207: A2M" amino acids 976 to 1057 (82 residues), 30.6 bits, see alignment 1.3e-10 PF07678: TED_complement" amino acids 1176 to 1281 (106 residues), 31.9 bits, see alignment 4.2e-11 PF21765: CUB_A2MG" amino acids 1443 to 1504 (62 residues), 92.4 bits, see alignment (E = 1e-29) PF17973: bMG10" amino acids 1505 to 1637 (133 residues), 82.3 bits, see alignment E=2e-26

Best Hits

Swiss-Prot: 100% identical to A2MG_ECOLI: Alpha-2-macroglobulin (yfhM) from Escherichia coli (strain K12)

KEGG orthology group: K06894, (no description) (inferred from 100% identity to ecd:ECDH10B_2686)

Predicted SEED Role

"Alpha-2-macroglobulin"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P76578 at UniProt or InterPro

Protein Sequence (1653 amino acids)

>b2520 hypothetical protein (NCBI) (Escherichia coli BW25113)
MKKLRVAACMLMLALAGCDNNDNAPTAVKKDAPSEVTKAASSENASSAKLSVPERQKLAQ
QSAGKVLTLLDLSEVQLDGAATLVLTFSIPLDPDQDFSRVIHVVDKKSGKVDGAWELSDN
LKELRLRHLEPKRDLIVTIGKEVKALNNATFSKDYEKTITTRDIQPSVGFASRGSLLPGK
VVEGLPVMALNVNNVDVNFFRVKPESLPAFISQWEYRNSLANWQSDKLLQMADLVYTGRF
DLNPARNTREKLLLPLGDIKPLQQAGVYLAVMNQAGRYDYSNPATLFTLSDIGVSAHRYH
NRLDIFTQSLENGAAQQGIEVSLLNEKGQTLTQATSDAQGHVQLENDKNAALLLARKDGQ
TTLLDLKLPALDLAEFNIAGAPGYSKQFFMFGPRDLYRPGETVILNGLLRDADGKALPNQ
PIKLDVIKPDGQVLRSVVSQPENGLYHFTWPLDSNAATGMWHIRANTGDNQYRMWDFHVE
DFMPERMALNLTGEKTPLTPKDEVKFSVVGYYLYGAPANGNTLQGQLFLRPLREAVSALP
GFEFGDIAAENLSRTLDEVQLTLDDKGRGEVSTESQWKETHSPLQVIFQGSLLESGGRPV
TRRAEQAIWPADALPGIRPQFASKSVYDYRTDSTVKQPIVDEGSNAAFDIVYSDAQGVKK
AVSGLQVRLIRERRDYYWNWSEDEGWQSQFDQKDLIENEQTLDLKADETGKVSFPVEWGA
YRLEVKAPNEAVSSVRFWAGYSWQDNSDGSGAVRPDRVTLKLDKASYRPGDTIKLHIAAP
TAGKGYAMVESSEGPLWWQEIDVRAQGLDLTIPVDKTWNRHDLYLSTLVVRPGDKSRSAT
PKRAVGVLHLPLGDENRRLDLALETPAKMRPNQPLTVKIKASTKNGEKPKQVNVLVSAVD
SGVLNITDYVTPDPWQAFFGQKRYGADIYDIYGQVIEGQGRLAALRFGGDGDELKRGGKP
PVNHVNIVVQQALPVTLNEQGEGSVTLPIGDFNGELRVMAQAWTADDFGSNESKVIVAAP
VIAELNMPRFMASGDTSRLTLDITNLTDKPQKLNVALTASGLLELVSDSPAAVELAPGVR
TTLFIPVRALPGYGDGEIQATISGLALPGETVADQHKQWKIGVRPAFPAQTVNYGTALQP
GETWAIPADGLQNFSPVTLEGQLLLSGKPPLNIARYIKELKAYPYGCLEQTASGLFPSLY
TNAAQLQALGIKGDSDEKRRASVDIGISRLLQMQRDNGGFALWDKNGDEEYWLTAYVMDF
LVRAGEQGYSVPTDAINRGNERLLRYLQDPGMMSIPYADNLKASKFAVQSYAALVLARQQ
KAPLGALREIWEHRADAASGLPLLQLGVALKTMGDATRGEEAIALALKTPRNSDERIWLG
DYGSSLRDNALMLSLLEENKLLPDEQYTLLNTLSQQAFGERWLSTQESNALFLAARTIQD
LPGKWQAQTSFSAEQLTGEKAQNSNLNSDQLVTLQVSNSGDQPLWLRMDASGYPQSAPLP
ANNVLQIERHILGTDGKSKSLDSLRSGDLVLVWLQVKASNSVPDALVVDLLPAGLELENQ
NLANGSASLEQSGGEVQNLLNQMQQASIKHIEFRDDRFVAAVAVDEYQPVTLVYLARAVT
PGTYQVPQPMVESMYVPQWRATGAAEDLLIVRP