Protein Info for b2480 in Escherichia coli BW25113

Name: bcp
Annotation: thioredoxin-dependent thiol peroxidase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08534: Redoxin
  • amino acids 5 to 138 (134 residues), 92.5 bits, E=3.5e-30
• PF00578: AhpC-TSA
  • amino acids 7 to 134 (128 residues), 141.5 bits, E=2e-45
• PF02630: SCO1-SenC
  • amino acids 11 to 131 (121 residues), 27.7 bits, E=3.6e-10

Best Hits

Swiss-Prot: 100% identical to BCP_ECOL6: Putative peroxiredoxin bcp (bcp) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03564, peroxiredoxin Q/BCP [EC: 1.11.1.15] (inferred from 100% identity to eco:b2480)

MetaCyc: 100% identical to thiol peroxidase (Escherichia coli K-12 substr. MG1655)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Thiol peroxidase, Bcp-type (EC 1.11.1.15)" in subsystem Thioredoxin-disulfide reductase (EC 1.11.1.15)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24

Sequence Analysis Tools

See P0AE52 at UniProt or InterPro

Protein Sequence (156 amino acids)

>b2480 thioredoxin-dependent thiol peroxidase (NCBI) (Escherichia coli BW25113)
MNPLKAGDIAPKFSLPDQDGEQVNLTDFQGQRVLVYFYPKAMTPGCTVQACGLRDNMDEL
KKAGVDVLGISTDKPEKLSRFAEKELLNFTLLSDEDHQVCEQFGVWGEKSFMGKTYDGIH
RISFLIDADGKIEHVFDDFKTSNHHDVVLNWLKEHA