Protein Info for b2289 in Escherichia coli BW25113

Name: lrhA
Annotation: DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 312 PF00126: HTH_1" amino acids 13 to 71 (59 residues), 65.5 bits, see alignment E=3.3e-22 PF03466: LysR_substrate" amino acids 97 to 283 (187 residues), 92.3 bits, see alignment E=2.8e-30

Best Hits

Swiss-Prot: 100% identical to LRHA_ECOLI: Probable HTH-type transcriptional regulator LrhA (lrhA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to eco:b2289)

Predicted SEED Role

"LysR family transcriptional regulator lrhA" in subsystem DNA-binding regulatory proteins, strays

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P36771 at UniProt or InterPro

Protein Sequence (312 amino acids)

>b2289 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes (NCBI) (Escherichia coli BW25113)
MISANRPIINLDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFAR
HGRNKLLTEHGIQLLGYARKILRFNDEACSSLMFSNLQGVLTIGASDESADTILPFLLNR
VSSVYPKLALDVRVKRNAYMAEMLESQEVDLMVTTHRPSAFKALNLRTSPTHWYCAAEYI
LQKGEPIPLVLLDDPSPFRDMVLATLNKADIPWRLAYVASTLPAVRAAVKAGLGVTARPV
EMMSPDLRVLSGVDGLPPLPDTEYLLCYDPSSNNELAQVIYQAMESYHNPWQYSPMSAPE
GDDSLLIERDIE