Protein Info for b2066 in Escherichia coli BW25113

Name: udk
Annotation: uridine/cytidine kinase (VIMSS)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00235: uridine kinase
  • amino acids 5 to 213 (209 residues), 326.1 bits, E=4.2e-102
• PF00485: PRK
  • amino acids 10 to 199 (190 residues), 158.5 bits, E=2e-50

Best Hits

Swiss-Prot: 100% identical to URK_ECO57: Uridine kinase (udk) from Escherichia coli O157:H7

KEGG orthology group: K00876, uridine kinase [EC: 2.7.1.48] (inferred from 100% identity to eco:b2066)

MetaCyc: 100% identical to uridine/cytidine kinase (Escherichia coli K-12 substr. MG1655)
Uridine kinase. [EC: 2.7.1.213, 2.7.1.48]; 2.7.1.48 [EC: 2.7.1.213, 2.7.1.48]; 2.7.1.48 [EC: 2.7.1.213, 2.7.1.48]; 2.7.1.48 [EC: 2.7.1.213, 2.7.1.48]

Predicted SEED Role

"Uridine kinase (EC 2.7.1.48) [C1]" (EC 2.7.1.48)

MetaCyc Pathways

• superpathway of pyrimidine ribonucleosides salvage (10/10 steps found)
• pyrimidine ribonucleosides salvage I (3/3 steps found)
• nucleoside and nucleotide degradation (archaea) (4/10 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.213 or 2.7.1.48

Sequence Analysis Tools

See P0A8F4 at UniProt or InterPro

Protein Sequence (213 amino acids)

>b2066 uridine/cytidine kinase (VIMSS) (Escherichia coli BW25113)
MTDQSHQCVIIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDCYYKDQSHLSMEE
RVKTNYDHPSAMDHSLLLEHLQALKRGSAIDLPVYSYVEHTRMKETVTVEPKKVIILEGI
LLLTDARLRDELNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQKTVRPMFLQFI
EPSKQYADIIVPRGGKNRIAIDILKAKISQFFE