Protein Info for b1838 in Escherichia coli BW25113

Name: pphA
Annotation: protein phosphatase 1 modulates phosphoproteins, signals protein misfolding (VIMSS)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00149: Metallophos
  • amino acids 18 to 188 (171 residues), 58 bits, E=9e-20

Best Hits

Swiss-Prot: 100% identical to PRP1_ECOLI: Serine/threonine-protein phosphatase 1 (pphA) from Escherichia coli (strain K12)

KEGG orthology group: K07313, serine/threonine protein phosphatase 1 [EC: 3.1.3.16] (inferred from 100% identity to eco:b1838)

MetaCyc: 100% identical to phosphoprotein phosphatase 1 (Escherichia coli K-12 substr. MG1655)
Protein-tyrosine-phosphatase. [EC: 3.1.3.48]; Phosphoprotein phosphatase. [EC: 3.1.3.48, 3.1.3.16]

Predicted SEED Role

"Ren protein"

KEGG Metabolic Maps

• T cell receptor signaling pathway

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.16, 3.1.3.48

Use Curated BLAST to search for 3.1.3.16 or 3.1.3.48

Sequence Analysis Tools

See P55798 at UniProt or InterPro

Protein Sequence (218 amino acids)

>b1838 protein phosphatase 1 modulates phosphoproteins, signals protein misfolding (VIMSS) (Escherichia coli BW25113)
MKQPAPVYQRIAGHQWRHIWLSGDIHGCLEQLRRKLWHCRFDPWRDLLISVGDVIDRGPQ
SLRCLQLLEQHWVCAVRGNHEQMAMDALASQQMSLWLMNGGDWFIALADNQQKQAKTALE
KCQHLPFILEVHSRTGKHVIAHADYPDDVYEWQKDVDLHQVLWSRSRLGERQKGQGITGA
DHFWFGHTPLRHRVDIGNLHYIDTGAVFGGELTLVQLQ