Protein Info for b0870 in Escherichia coli BW25113

Name: ltaE
Annotation: L-allo-threonine aldolase, PLP-dependent (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to LTAE_ECOLI: Low specificity L-threonine aldolase (ltaE) from Escherichia coli (strain K12)

KEGG orthology group: K01620, threonine aldolase [EC: 4.1.2.5] (inferred from 100% identity to eco:b0870)

MetaCyc: 100% identical to low-specificity L-threonine aldolase (Escherichia coli K-12 substr. MG1655)
Threonine aldolase. [EC: 4.1.2.48, 4.1.2.5]; LTAA-RXN [EC: 4.1.2.48, 4.1.2.5, 4.1.2.49]; 4.1.2.48 [EC: 4.1.2.48, 4.1.2.5, 4.1.2.49]; Phenylserine aldolase. [EC: 4.1.2.48, 4.1.2.5, 4.1.2.49, 4.1.2.26]

Predicted SEED Role

No annotation

MetaCyc Pathways

superpathway of L-threonine metabolism (16/18 steps found)
L-threonine degradation IV (2/2 steps found)
glycine biosynthesis IV (1/1 steps found)

KEGG Metabolic Maps

Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.26 or 4.1.2.48 or 4.1.2.49 or 4.1.2.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P75823 at UniProt or InterPro

Protein Sequence (333 amino acids)

>b0870 L-allo-threonine aldolase, PLP-dependent (NCBI) (Escherichia coli BW25113)
MIDLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQ
ANLVALLSHCERGEEYIVGQAAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKI
KPDDIHFARTKLLSLENTHNGKVLPREYLKEAWEFTRERNLALHVDGARIFNAVVAYGCE
LKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMTGGGMRQSGILAAAGIY
ALKNNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRVGEENAAALGEYMKARNVL
INASPIVRLVTHLDVSREQLAEVAAHWRAFLAR