Protein Info for b0112 in Escherichia coli BW25113

Name: aroP
Annotation: aromatic amino acid transporter (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 47 to 63 (17 residues), see Phobius details amino acids 86 to 108 (23 residues), see Phobius details amino acids 125 to 143 (19 residues), see Phobius details amino acids 154 to 176 (23 residues), see Phobius details amino acids 196 to 220 (25 residues), see Phobius details amino acids 241 to 263 (23 residues), see Phobius details amino acids 283 to 303 (21 residues), see Phobius details amino acids 332 to 353 (22 residues), see Phobius details amino acids 359 to 379 (21 residues), see Phobius details amino acids 400 to 422 (23 residues), see Phobius details amino acids 428 to 446 (19 residues), see Phobius details PF00324: AA_permease" amino acids 19 to 455 (437 residues), 481.7 bits, see alignment E=2.4e-148 PF13520: AA_permease_2" amino acids 23 to 438 (416 residues), 136.5 bits, see alignment E=1.3e-43

Best Hits

Swiss-Prot: 100% identical to AROP_ECOLI: Aromatic amino acid transport protein AroP (aroP) from Escherichia coli (strain K12)

KEGG orthology group: K11734, aromatic amino acid transport protein AroP (inferred from 100% identity to eco:b0112)

MetaCyc: 100% identical to aromatic amino acid:H+ symporter AroP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-56; TRANS-RXN-76; TRANS-RXN-77

Predicted SEED Role

"Aromatic amino acid transport protein AroP" in subsystem Aromatic amino acid degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P15993 at UniProt or InterPro

Protein Sequence (457 amino acids)

>b0112 aromatic amino acid transporter (NCBI) (Escherichia coli BW25113)
MMEGQQHGEQLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAF
LIMRQLGEMVVEEPVAGSFSHFAYKYWGSFAGFASGWNYWVLYVLVAMAELTAVGKYIQF
WYPEIPTWVSAAVFFVVINAINLTNVKVFGEMEFWFAIIKVIAVVAMIIFGGWLLFSGNG
GPQATVSNLWDQGGFLPHGFTGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQ
VIYRILIFYIGSLAVLLSLMPWTRVTADTSPFVLIFHELGDTFVANALNIVVLTAALSVY
NSCVYCNSRMLFGLAQQGNAPKALASVDKRGVPVNTILVSALVTALCVLINYLAPESAFG
LLMALVVSALVINWAMISLAHMKFRRAKQEQGVVTRFPALLYPLGNWICLLFMAAVLVIM
LMTPGMAISVYLIPVWLIVLGIGYLFKEKTAKAVKAH