Protein Info for UW163_RS22980 in Ralstonia solanacearum UW163

Annotation: two-component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 461 transmembrane" amino acids 6 to 22 (17 residues), see Phobius details amino acids 30 to 50 (21 residues), see Phobius details amino acids 62 to 81 (20 residues), see Phobius details amino acids 93 to 115 (23 residues), see Phobius details amino acids 135 to 154 (20 residues), see Phobius details amino acids 166 to 185 (20 residues), see Phobius details amino acids 192 to 211 (20 residues), see Phobius details PF16927: HisKA_7TM" amino acids 9 to 216 (208 residues), 41 bits, see alignment E=3.2e-14 PF02518: HATPase_c" amino acids 352 to 457 (106 residues), 77.3 bits, see alignment E=1.9e-25 PF14501: HATPase_c_5" amino acids 354 to 449 (96 residues), 27.6 bits, see alignment E=3.6e-10

Best Hits

KEGG orthology group: K00936, [EC: 2.7.3.-] (inferred from 89% identity to rso:RS05203)

Predicted SEED Role

"Signal transduction histidine kinase"

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (461 amino acids)

>UW163_RS22980 two-component sensor histidine kinase (Ralstonia solanacearum UW163)
MHALLPAFVSSLFLFYGIHVLMTRGRTRASLAFFGVTVLTGLWQGLWAFLFEAPDAATAR
MLAKLGWVAILPLPTVLYHFAVEMAEHPDDHRWLIASYALAGVLVVLLLGSDLVIDGVRR
FSFGFYPKAGPLEAVHIAQTTALVFRSIWLLYAAQRHATAEKRRRLQLCLCGVALYSLSA
ADYAVNYGLAPYPPGVVFIAGSPVIMAFAILKLDLMRPYALAATVAHEVRTPLATIRLQA
AEIASAWPDLLHGYRLAIDHGLCEPPRHPALMERLPRLAGAIADEVACAHSVIDMALASV
TLERLDRRTFAPHSLRACVDMALTRYPFQYGERDRVRVQAFSADWHFVGSDTLLMHVLFN
LLKNALYAIRIAHQGHIEITARQDGDSCVLTIRDSAMGIPPSVQRRIFDPFFSTKLADNG
SGVGLTFCRRVMEAFGGRIQCESVVGEYTLFTLHLPCRPAA